食源性多酚干预酒精性肝病研究进展

Research Progress on the Intervention of Food-borne Polyphenols in Alcoholic Liver Disease

酒精性肝病是因大量或高频率饮酒而导致的肝脏疾病,初期表现为酒精性脂肪肝,进而发展成酒精性肝炎、肝硬化,甚至肝癌。酗酒会导致肝细胞坏死与肝衰竭。目前寻找有效预防或改善酒精性肝病的活性成分成为研究热点。多酚类化合物广泛存在于蔬菜、水果、谷物等食物中,具有干预酒精性肝病的作用,而其对酒精性肝病的干预作用鲜有系统性的论述。本文综述酒精性肝病的发病机制以及具有干预酒精性肝损伤的食源性多酚的调控机理,以期为研发具有缓解酒精性肝损伤作用的多酚类保健食品提供一定的理论依据。

Alcoholic liver disease is a liver disease caused by heavy or high frequency of alcohol consumption,which initially manifests as alcoholic fatty liver,and progresses to alcoholic hepatitis,cirrhosis,and even liver cancer.Alcoholism can lead to liver cell death and liver failure.At present,the search for effective active ingredients to prevent or improve alcoholic liver disease has become a research hotspot.Polyphenols are widely found in vegetables,fruits,cereals et al.,and affect the intervention of alcoholic liver disease.However,the intervention effect on alcoholic liver disease has rarely been systematically discussed.In this review,the pathogenesis of alcoholic liver disease and the regulation mechanism of food-borne polyphenols that could interfere with alcoholic liver injury were summary to provide a theoretical basis for the research and develop polyphenol health food with the effect of alleviating alcoholic liver injury.