滋肾育胎丸治疗复发性流产临床研究

Clinical Study on the Treatment of Recurrent Spontaneous Abortion with Zishen Yutai Pill

目的探讨滋肾育胎丸治疗复发性流产的临床疗效。方法选取既往有复发性流产史的早期妊娠妇女84例,采用随机数字表法将其分为治疗组与对照组,每组42例。对照组给予常规对症支持治疗,治疗组在对照组基础上加用滋肾育胎丸,2组均持续服药至妊娠12+6周。比较2组血清孕酮(progesterone,P)、人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)水平,以及血小板计数和D-二聚体等凝血功能相关指标,并比较2组保胎成功率和持续妊娠情况。结果治疗后,2组hCG水平均较治疗前增加(P均<0.05),且治疗组hCG水平明显高于对照组(P<0.05)。2组血清P、血小板计数、D-二聚体等指标治疗前后及组间比较,差异均无统计学意义(P>0.05)。随访至妊娠12+6周,对照组保胎成功率为61.90%(26/42),治疗组保胎成功率为71.43%(30/42);保胎成功率组间比较,差异无统计学意义(P>0.05)。结论常规保胎方案联合滋肾育胎丸治疗复发性流产有促进妊娠、提高患者保胎成功率的趋势,但有待进一步研究。

Objective To explore the clinical efficacy of Zishen Yutai pill in the treatment of recurrent spontaneous abortion.Methods Eighty-four early pregnant women with a history of recurrent spontaneous abortion were selected and randomly divided into the treatment group and the control group using a random number table method,with 42 cases in each group.The control group received routine symptomatic supportive treatment,while the treatment group received an additional treatment of Zishen Yutai pill on the basis of the control group.Both groups continued to take the medication until 12+6 weeks of pregnancy.The levels of serum progesterone(P)and human chorionic gonadotropin(hCG),as well as coagulation related indicators such as platelet count and D-dimer were compared in the two groups.And the success rate of maintaining pregnancy and the duration of pregnancy were also compared.Results After treatment,the levels of hCG in both groups increased compared to those before treatmen(all P<0.05),and the hCG of the treatment group were significantly higher than that of the control group(P<0.05).The comparison of serum P,platelet count and D-dimer before and after treatment,as well as between the two groups were no statistically significant difference(P>0.05).Follow up to 12+6 weeks of pregnancy,the success rate in the control group was 61.90%(26/42),while the treatment group was 71.43%(30/42).There was no statistically significant difference in the success rate of maintaining pregnancy between the two groups(P>0.05).Conclusion The combination of conventional tocolytic therapy and Zishen Yutai pill in the treatment of recurrent spontaneous abortion had a trend of promoting pregnancy and improving the success rate of fetal preservation,but further research is needed.