抑制信号传导通路的纳米递药系统在三阴性乳腺癌治疗中的研究进展

Research progress of nano-drug delivery system that inhibits signaling pathways in therapy of triple-negative breast cancer

PI3K/AKT/m TOR、Hippo/YAP、Notch、Wnt/β-catenin、TGF-β等信号传导通路参与了三阴性乳腺癌(TNBC)的增殖、浸润、转移和耐药等恶性生物学行为。常规化疗药物不良反应严重,纳米技术的应用可改善这一状况。基于抑制信号传导通路的纳米递药系统可负载常规化疗药物,高效阻断癌细胞增殖过程,遏制TNBC进展,靶向治疗优势明显,对正常组织的损伤明显减轻,给患者带来更多获益。

Signaling pathways such as PI3K/AKT/mTOR,Hippo/YAP,Notch,Wnt/βB-catenin,and TGF-βplay the critical role in the malignant biological behaviors of triple-negative breast cancer(TNBC),including proliferation,invasion,metastasis,and drug resistance.However,conventional chemotherapy drugs often lead to severe adverse reactions,and the utilization of nanotechnology presents a promising solution to this issue.Nano-drug delivery system based on inhibiting signal transduction pathways can carry conventional chemotherapy drugs,block the proliferation of cancer cells,and impede the progression of TNBC.This approach not only offers advantages in targeted therapy but also reduces tissue damage significantly,giving patients more benefits in the future.