光动力治疗与肿瘤细胞免疫原性死亡

Photodynamic therapy and immunogenic cell death in tumor cells

抗癌治疗的成功依赖于免疫系统介导的长期特异性抗肿瘤免疫反应。而近年来肿瘤细胞免疫原性死亡(ICD)被认为是诱发机体产生这种反应的重要方式。光动力疗法(PDT)已被证实可引发肿瘤细胞免疫原性死亡。ICD的核心是垂死癌细胞表达或释放危险相关分子模式(DAMPs),这些DAMPs对激活树突状细胞(DC)和激活T细胞适应性免疫反应至关重要,并导致长期免疫记忆的形成。本文将介绍ICD的研究进展以及通过改善肿瘤微环境缺氧和光敏剂的亚细胞定位增强PDT诱导ICD的能力的探索。

The success of cancer therapy relies on long-term specific anti-tumor immune responses mediated by the immune system.In recent years,immunogenic cell death(ICD)has been recognized as an important mechanism for inducing such responses.Photodynamic therapy(PDT)has been demonstrated to induce immunogenic cell death in tumor cells.The core of ICD is the expression or release of damage-associated molecular patterns(DAMPs)by dying cancer cells,which are crucial for activating dendritic cells(DCs)and adaptive immune responses by T cells,leading to the formation of long-term immune memory.We will review the research progress on ICD and explore the enhancement of PDT-induced ICD by improving tumor microenvironment hypoxia and subcellular localization of photosensitizers.