2023年湖南省市售婴幼儿配方乳粉中丙烯酰胺污染状况及暴露风险初步评估

Contamination Characteristics and Preliminary Exposure Risk Assessment of Acrylamide in Infant Formula Sold in Hunan Province in 2023

目的:调查2023年湖南省市售婴幼儿配方乳粉中丙烯酰胺污染状况,并对0~36月龄婴幼儿经乳粉摄入丙烯酰胺的暴露风险进行评估。方法:随机采集湖南省市售婴幼儿配方乳粉23份,采用稳定同位素稀释-超高效液相色谱-串联质谱法测定样品中丙烯酰胺含量,结合婴幼儿配方乳粉推荐消费量,估算0~36月龄婴幼儿丙烯酰胺暴露量。结果:23份样品中丙烯酰胺的检出率为60.9%(检出限为0.3μg·kg^(-1)),均值2.4±2.4μg·kg^(-1),各月龄婴幼儿每日经婴幼儿配方乳粉摄入的丙烯酰胺为0.021~0.025μg·kg^(-1)bw,其暴露限值均高于10000。结论:2023年湖南省市售婴幼儿配方乳粉中丙烯酰胺污染较轻,对婴幼儿健康影响有限。

Objective:To investigate acrylamide contamination in infant formula sold in Hunan province in 2023,and assess the acrylamide exposure risk in 0 to 36 months old infants from formula.Method:A total of 23 samples of infant formula were randomly collected,the content of acrylamide in the samples was determined by stable isotope dilution with high performance liquid chromatography-tandem mass spectrometry,and the acrylamide exposure of 0 to 36 months infants was calculated according to the recommended consumption of infant formula.Result:The detection rate of acrylamide was 60.9%(limit of detection is 0.3μg·kg^(-1)),the average content was 2.4±2.4μg·kg^(-1),the daily intake acrylamide of infant formula was 0.021 to 0.025μg·kg^(-1)bw,and the margin of exposure was higher than 10000.Conclusion:Acrylamide in infant formulas sold in Hunan province in 2023 were less polluted and their intake was within the safe range.