铁死亡与继发性肾脏病

Ferroptosis and secondary nephrosis

继发性肾脏病是继发于其他基础疾病的一系列慢性肾脏病,主要表现为肾结构和功能异常、代谢紊乱,是导致终末期肾病的重要原因之一,具有发病率高、危害大等特点。铁是人体细胞中必需的金属元素,铁死亡是一种非传统形式的、铁依赖性的细胞死亡,其主要机制包括铁蓄积、脂质代谢紊乱、氨基酸代谢异常和抗氧化系统损伤。近年研究发现铁死亡参与继发性肾脏病的发生、发展,不同继发性肾脏病中铁死亡的发生机制不同。深入、系统地了解铁死亡与继发性肾脏病之间的关联及其特异性调控机制,可为继发性肾脏病的诊疗、防治及预后评估提供理论依据,为探索继发性肾脏病新的临床治疗靶点奠定基础。

Secondary nephrosis is a series of chronic kidney diseases secondary to other underlying diseases,mainly manifesting as structural and functional abnormalities of the kidneys and metabolic disorders.It is one of the important causes of end-stage renal disease,with high morbidity and significant harm.Iron is an essential metal element in human cells,and ferroptosis is a non-traditional form of iron-dependent cell death,and its main mechanisms include iron accumulation,lipid metabolism disorders,abnormal amino acid metabolism,and damage to the antioxidant system.Recently studies have found that ferroptosis is involved in the occurrence and progression of secondary nephrosis,and the mechanism of ferroptosis in different secondary nephrosis vary.Therefore,an in-depth and systematic understanding of the association between ferroptosis and secondary nephrosis,as well as their specific regulatory mechanisms,can provide a theoretical basis for the diagnosis,prevention,treatment,and prognosis assessment of secondary nephrosis,laying the foundation for exploring new clinical therapeutic targets for secondary nephrosis.