健康体检人群高尿酸血症与血脂、血糖、血压的相关性探讨

Correlation between hyperuricemia and blood lipids,blood glucose,blood pressure in a population undergoing health examination

目的 分析健康体检人群高尿酸血症(HUA)同血压、血糖、血脂等指标的相关性。方法 218例健康体检者,其中106例高尿酸血症患者作为实验组, 112例尿酸正常患者作为对照组。记录两组健康体检者的体质量指数(BMI)、动脉粥样硬化(AS)发生率、吸烟、饮酒、腰围情况;检测血清指标,包括尿素氮(BUN)、甘油三酯(TG)、总胆固醇(TC)、空腹血糖(GLU);并对舒张压(DBP)、收缩压(SBP)水平进行检测,分析健康体检人群高尿酸血症的危险因素。结果 两组男性和女性体检者的TC、GLU、BMI、DBP、SBP、AS发生率、TG、饮酒占比、腰围分别进行对比,差异均有统计学意义(P<0.05);两组男性和女性体检者的BUN水平、吸烟占比情况对比,差异无统计学意义(P>0.05)。实验组的AS发生率19.8%、TC(5.0±0.8)mmol/L、DBP(84.0±7.1)mm Hg(1 mm Hg=0.133 kPa)、饮酒占比30.2%、BMI(26.8±4.2)kg/m~2、TG(2.0±0.3)mmol/L、GLU(5.7±0.7)mmol/L、腰围(85.6±10.5)cm、SBP(130.4±3.6)mm Hg与对照组的3.6%、(4.7±0.7)mmol/L、(80.5±8.6)mm Hg、8.0%、(24.6±3.7)kg/m~2、(1.5±0.3)mmol/L、(5.2±0.5)mmol/L、(62.5±10.2)cm、(127.8±3.3)mm Hg对比,差异有统计学意义(P<0.05)。两组吸烟情况与BUN水平比较,差异无统计学意义(P>0.05)。多因素Logistic回归分析显示, AS发生率、TC、TG、BMI、GLU、腰围是体检人员发生高尿酸血症的独立影响因素(P<0.05)。结论 尿酸水平的升高同血脂、血糖、BMI、腰围等的变化存在相关性,尿酸水平升高是发生及发展AS的一个重要危险因素。

Objective To analyze the correlation between hyperuricemia(HUA)and blood lipids,blood glucose,blood pressure in a population undergoing health examination.Methods 218 subjects undergoing health examination,of which 106 patients with hyperuricemia selected as the experimental group and 112 patients with normal uric acid selected as the control group.The body mass index(BMI),incidence of atherosclerosis(AS),smoking,drinking and waist circumference of the two groups were recorded.The serum indexes,including blood urea nitrogen(BUN),triglyceride(TG),total cholesterol(TC),fasting blood glucose(GLU),as well as diastolic blood pressure(DBP)and systolic blood pressure(SBP)were detected to analyze the risk factors of hyperuricemia in subjects undergoing health examination.Results The TC,GLU,BMI,DBP,SBP,incidence of AS,TG,alcohol consumption ratio and waist circumference of male and female subjects undergoing health examination in the two groups were compared respectively,and the difference was statistically significant(P<0.05).BUN level and smoking proportion of male and female subjects undergoing health examination in the two groups were compared,and the difference was not statistically significant(P>0.05).The incidence of AS in the experimental group was 19.8%,TC was(5.0±0.8)mmol/L,DBP was(84.0±7.1)mm Hg(1 mm Hg=0.133 kPa),alcohol consumption accounted for 30.2%,BMI was(26.8±4.21)kg/m2,TG was(2.0±0.3)mmol/L,GLU was(5.7±0.76)mmol/L,waist circumference was(85.6±10.5)cm,and SBP was(130.4±3.6)mm Hg,and those in the control group were 3.6%,(4.7±0.7)mmol/L,(80.5±8.6)mm Hg,8.0%,(24.69±3.7)kg/m2,(1.56±0.3)mmol/L,(5.20±0.5)mmol/L,(62.51±10.2)cm,and(127.88±3.3)mm Hg;the difference was statistically significant(P<0.05).There was no significant difference in smoking status and BUN level between the two groups(P>0.05).Multivariate Logistic regression analysis showed that the incidence of AS,TC,TG,BMI,GLU and waist circumference were independent influencing factors for the occurrence of hyperuricemia(P<0.05).Conclusion The increase of uric acid level is correlated with the changes of blood lipid,blood glucose,BMI,waist circumference.The increase of uric acid level is an important risk factor for the occurrence and development of AS.