半夏泄心汤全方及其拆方联合美沙拉嗪治疗溃疡性结肠炎的临床疗效及对炎性因子水平的影响

The clinical efficacy of Banxia Xiexin decoction and its discombination combined with mesalazine in the treatment of ulcerative colitis and its impact on the levels of inflammatory factors in patients

目的:探究半夏泄心汤全方及其拆方联合美沙拉嗪治疗溃疡性结肠炎的应用效果。方法:选取2023年5月~2024年5月在吉林省人民医院消化科和中医科诊治的120例中度溃疡性结肠炎患者作为研究对象。随机分为对照组(24例)与观察组(96例)。观察组分为全方组、辛开组、苦降组、甘补组,每组24例。对照组与观察组同时给药美沙拉嗪肠溶片。连续治疗3个月,比较对照组与观察组治疗前后的肠道内窥镜及外周血血清炎性因子水平。记录药物的不良反应。结果:观察组与对照组均表现出不同程度的治疗效果。对照组美沙拉嗪可以通过抑制炎性反应达到治疗结肠炎的作用。半夏泻心汤及拆方联合美沙拉嗪治疗结肠炎表现出良好的效果。辛开组具有温暖中焦脾胃的功效,能够偏向缓解患者呕吐,腹痛等症状。苦降组由于具有较多生物碱、黄酮类成分,具有较强的止泻、抗菌、消炎的功效。甘补组虽然能够大补元气提高患者免疫力,但由于患者肠道功能退化,并不能起到良好的效果。结论:半夏泻心汤全方联合美沙拉嗪可以有效缓解结肠炎症状并提高疗效。不同组方偏向不同,但单纯运用甘补类药材,不适宜肠胃功能较差的患者。

Objective To investigate the effect of Banxia Xiexin decoction and its discombination combined with mesalazine in the treatment of ulcerative colitis.Method A total of 120 patients with moderate ulcerative colitis diagnosed and treated in Gastroenterology and Traditional Chinese Medicine Department of Jilin Provincial People's Hospital from May 2023 to May 2024 were selected as the study objects.They were randomly divided into control group(24 cases)and observation group(96 cases).The observation group was divided into whole prescription group,Xinkai group,Kudescending group and Ganbu group,with 24 cases in each group.Control group and observation group were simultaneously given mesalazine enteric-coated tablets.After continuous treatment for 3 months,the changes of intestinal endoscopy and serum inflammatory factors in the control group and the observation group before and after treatment were compared.Record adverse drug reactions.Results Both the observation group and the control group showed different degrees of therapeutic effect.The control group mesalazine can achieve the effect of treating colitis by anti-inflammatory.Banxia Xiexin Decoction and dissolving prescription combined with mesalazine showed a good effect in the treatment of colitis.Xinkai group had the effect of warming the spleen and stomach in the middle and relieving the symptoms of vomiting and abdominal pain.Due to more alkaloid and flavonoid components,Kudescending group had strong anti-diarrhea,antibacterial and anti-inflammatory effects.Although the decoction group can greatly replenish the vitality and improve the immunity of patients,it can not play a good effect due to the degeneration of the intestinal function of patients.Conclusion Banxia Xiexin Decoction combined with mesalazine can effectively relieve the discomfort caused by colitis and improve the curative effect.Different groups of prescriptions have different preferences,but the simple use of herbal supplements is not suitable for patients with poor gastrointestinal function.