基于气滞血瘀理论探讨五虎口服液治疗急性软组织损伤的疗效

Study on the curative effect of Wuhu oral liquid on acute soft tissue injury based on the theory of qi stagnation and blood stasis

目的基于气滞血瘀理论探讨五虎口服液治疗急性软组织损伤的疗效。方法选取2020年9月—2022年9月于我院就诊的130例急性软组织损伤(ASTI)患者作为研究对象,通过随机数字表法分为研究组(65例)和对照组(65例),对照组给予吲哚美辛巴布膏治疗,研究组在对照组基础上给予五虎口服液治疗。并建立五虎口服液治疗ASTI的效益与风险多准则决策分析模型。采用RevMan5.3软件合并数据,得出各效益指标和风险指标效应值,采用Hiview3软件计算出研究组和对照组的效益值、风险值和效益-风险总值,改变效益-风险中一级指标的权重来评价模型的灵敏度。结果治疗后,研究组患者在压痛、瘀斑、肿胀、功能障碍、VAS评分、疼痛缓解时间、肿胀缓解时间、不良反应、临床疗效、功能障碍缓解时间方面改善显著优于对照组(均P<0.05);且IL-6、TNF-α水平均显著低于对照组(P<0.05),其余指标比较差异无统计学意义(P>0.05);研究组和对照组的效益值分别为66和50,风险值分别为71和83,效益-风险总值分别为67、57。研究组的效益-风险总值最高。无论效益-风险的相对权重如何改变,模型评价结果均保持不变,表明该模型稳定型良好。结论基于气滞血瘀理论下,五虎口服液治疗ASTI获益高于风险,可降低不良反应的发生率,能够为临床合理用药提供依据。

Objective Based on the theory of qi stagnation and blood stasis,to explore the therapeutic effect of Wuhu oral liquid on acute soft tissue injury.Methods 130 patients with acute soft tissue injury(ASTI)who were hospitalized in our hospital from September 2020 to September 2022 were selected as the study objects.The study objects were divided into the study group(65 cases)and the control group(65 cases)according to the ratio of 1∶1 by the method of random number table.The control group was treated with indomethacin cataplasm,and the study group was treated with Wuhu oral liquid on the basis of the control group.The multi criteria decision-making analysis model of benefit and risk of Wuhu oral liquid in treating ASTI was established.The RevMan5.3 software was used to combine data to obtain the effect values of various benefit indicators and risk indicators and Used Hiview3 software to calculate the benefit value,risk value and benefit risk total value of the study group and the control group,changed the weight of the first level indicators in benefit risk and evaluate the sensitivity of the model.Results After treatment,the patients in the study group were significantly better than those in the control group in tenderness,ecchymosis,swelling,dysfunction,VAS score,pain relief time,swelling relief time,dysfunction relief time,clinical efficacy and adverse reactions;and the levels of TNF-α,IL-6 in the control group were significantly lower than those in the control group.The benefit values of the study group and the control group were 66 and 50 respectively,the risk values were 71 and 93 respectively,and the total benefit risk values were 67 and 57 respectively.The total benefit risk value of the research group was the highest.No matter how the relative weight of benefit risk changed,the model evaluation results remained unchanged,indicating that the model was stable.Conclusion Based on the theory of qi stagnation and blood stasis,the benefits of Wuhu oral liquid in treating ASTI are higher than the risks,and it can reduce the incidence of adverse reactions and provide a basis for rational clinical medication.