睡眠节律紊乱与焦虑症状对更年期女性记忆能力的影响及其交互作用

The impact and interaction of sleep rhythm disorder and anxiety symptom on the memory ability of menopausal women

目的探究睡眠节律紊乱与焦虑症状对更年期女性记忆能力的影响及其交互作用。方法选取282例更年期女性患者作为研究对象,依据是否存在记忆减退分为减退组(n=97)和未减退组(n=185)。通过Logistic回归分析睡眠情况和焦虑情况与更年期女性记忆能力的关系,并分析二者的交互作用。结果两组在年龄、居住状况、受教育水平、高血压、家庭支持、体育锻炼、社交活动、E2方面比较差异均有统计学意义(P<0.05)。减退组平均睡眠时长、社会时差、日间过度嗜睡程度、焦虑总分均高于未减退组(P<0.05)。回归分析结果显示,家庭支持、体育锻炼、社交活动、E2、平均睡眠时长≥9 h、社会时差≥1 h、日间嗜睡、焦虑总分均是更年期女性记忆能力的独立影响因素(P<0.05)。交互作用分析结果显示,睡睡眠节律紊乱情况与中、重度焦虑有正交互作用。结论睡眠节律紊乱与焦虑症状是更年期女性记忆能力的危险因素,二者之间存在正向交互作用,随着睡眠紊乱与焦虑症状的加重,更年期女性记忆能力减退更为显著。

Objective To explore the impact and interaction of sleep rhythm disorder and anxiety symptom on the memory ability of menopausal women.Methods A total of 282 menopausal females were selected as the research subjects and were divided into hypomnesia group(n=97)and non-hypomnesia group(n=185)based on the presence of hypomnesia.Logistic regression analysis was used to explore the relationships among sleep,anxiety and memory ability in menopausal women,and the interactions among them were also analyzed.Results There existed significant differences in age,residence condition,educational level,hypertension,family support,physical exercise,social activities and E2 between two groups(P<0.05).The average sleep duration,social time difference,excessive daytime sleepiness,and anxiety score in hypomnesia group were significantly higher than those in non-hypomnesia group(P<0.05).Regression analysis showed that family support,physical exercise,social activities,E2,average sleep duration≥9 hours,social time difference≥1 hour,daytime sleepiness,and anxiety score were independent influencing factors on the memory ability of menopausal women(P<0.05).The interaction analysis showed that there was a positive interaction between sleep rhythm disorder and moderate to severe anxiety.Conclusion Sleep rhythm disorder and anxiety symptom are risk factors for memory ability in menopausal women,and there is a positive interaction between them.The worsening sleep rhythm disorder and anxiety symptom will aggravate hypomnesia.