MIF和MBL2基因多态性与双相情感障碍患者自杀未遂的关联

Relationships between MIF and MBL2 gene polymorphisms and suicide attempts in patients with bipolar disorder

目的探讨巨噬细胞抑制因子(MIF)和甘露糖结合凝集素2(MBL2)基因多态性与双相情感障碍(BD)患者自杀未遂的关系。方法选取321例BD患者作为研究对象,依据自杀未遂定义分为BD伴自杀未遂组120例,BD不伴自杀未遂组201例。采用聚合酶链反应-限制性片断长度多态性技术检测MIF和MBL2基因多态性。通过计算比值比(OR)和95%置信区间(95%CI)评估MIF、MBL2基因多态性与BD患者自杀未遂的关联性,采用Logistic回归分析探讨多态性位点基因型与BD易感性的关系。结果两组MIF、MBL2各基因型分布频率比较,差异存在统计学意义(P<0.001)。BD伴自杀未遂组MIF、MBL2 A等位基因频率高于BD不伴自杀未遂组,MIF G等位基因、MBL2 T等位基因频率低于BD不伴自杀未遂组(P<0.05)。MIF AA基因型、MBL2 A等位基因频率为BD患者自杀未遂发生的危险因素(P<0.05)。结论MIFAA基因型、MBL2 A等位基因频率与BD患者自杀未遂具有一定相关性。

Objective To explore the relationships between macrophage inhibitory factor(MIF)and mannose-binding lectin 2(MBL2)gene polymorphisms and suicide attempts in patients with bipolar disorder(BD).Methods A total of 321 BD patients were selected as the research objects,and divided into BD with suicide attempt group(120 cases)and BD without suicide attempt group(201 cases)according to the definition of suicide attempt.The polymorphisms of MIF and MBL2 were detected by polymerase chain reaction-restriction fragment length polymorphism.Odds ratio(OR)and 95%confidence interval(95%CI)were calculated to evaluate the associations between MIF and MBL2 gene polymorphisms and suicide attempts in BD patients.Logistic regression analysis was used to explore the relationship between polymorphism loci genotype and BD susceptibility.Results There existed significant differences in the distribution frequencies of MIF and MBL2 genotypes between BD with and without suicide attempt groups(P<0.001).BD with suicide attempt group showed higher frequencies of A alleles of MIF and MBL2 genes,and lower frequencies of MIF G allele and MBL2 T allele than BD without suicide attempt group(P<0.05).MIF AA genotype and MBL2 A allele frequency were risk factors for suicide attempts in BD patients(P<0.05).Conclusion MIF AA genotype and MBL2 A allele frequency are correlated with suicide attempts in BD patients.