非酒精性脂肪肝病与冠状动脉粥样硬化相关CT影像标志物的研究进展

Research progress of CT imaging markers associated with nonalcoholic fatty liver disease and coronary atherosclerosis

非酒精性脂肪性肝病(NAFLD)已经发展成为全世界最常见的慢性肝脏疾病,并且发病率逐年增加。近年来,越来越多的研究证明,NAFLD与冠状动脉粥样硬化存在多种共同的病理生理学机制,如胰岛素抵抗、全身炎症,NAFLD可以促进冠状动脉粥样硬化的发生发展,与动脉粥样硬化心血管疾病密切相关,是动脉粥样硬化心血管疾病的独立危险因素。本文拟从NAFLD促进冠状动脉粥样硬化的病理生理学机制及NAFLD与冠状动脉粥样硬化影像标志物的相关研究两方面阐述NAFLD与动脉粥样硬化心血管疾病相关性的研究进展,旨在提高对早期冠状动脉粥样硬化危险因素的识别,为未来NAFLD和ASCVD的个体化临床诊疗及研究提供思路。

Non-alcoholic fatty liver disease(NAFLD)has emerged as the most prevalent chronic liver disease worldwide,with an increasing incidence on an annual basis.In recent years,a growing body of evidence indicates that NAFLD and coronary atherosclerosis share a multitude of pathophysiological mechanisms,including insulin resistance and systemic inflammation.NAFLD not only promotes the occurrence and development of coronary atherosclerosis,but also is closely related to atherosclerotic cardiovascular disease and represents an independent risk factor for this disease.This article aims to review the research progress of the correlation between NAFLD and atherosclerotic cardiovascular disease from two different but complementary perspectives,including the pathophysiological mechanism of NAFLD promoting coronary atherosclerosis and the correlation studies on imaging markers of NAFLD and coronary atherosclerosis,in order to enhance the identification of risk factors for early coronary atherosclerosis,and provide insights for future individualized clinical diagnosis,treatment and research of NAFLD and atherosclerotic cardiovascular disease.