金属有机骨架材料沸石咪唑酯骨架-8在抗菌方面的应用及研究进展

Application and research progress of metal-organic skeleton material ZIF-8 in antibacterial field

细菌是引起慢性传染病和感染的主要原因。用抗生素杀灭细菌、消除感染是当今普遍使用的有效医疗手段,但是抗生素的滥用和误用导致越来越多的细菌出现耐药性。此外,现有给药方式常导致大量药物难以到达作用位点,造成药效浪费。在应对抗菌困境的各类策略中,抗菌纳米材料已成为一种被广泛认可的新兴方法。沸石咪唑酯骨架-8(ZIF-8)是一种在连接节点可生长药物的金属-有机骨架材料,因具有生物相容性好、结构稳定、pH响应特性及其靶向给药且减少细菌耐药性产生的能力等特点,成为目前研究较为广泛的抗菌方式之一。同时,大量研究表明,ZIF-8有利于保持药物活性,具有潜在的临床抗菌应用可能。综述了ZIF-8的抗菌机理、在抗菌方面的应用及研究进展,并对该领域未来发展中面临的挑战和前景进行了总结与展望。

Bacteria are a major cause of chronic infectious diseases and infections.Using antibiotics is the most commonly used method to kill bacteria and eliminate infection,but the abuse and misuse of antibiotics have led to increasing drug-resistance bacteria.In addition,the existing drug delivery methods often make it difficult for drugs to reach the action site,resulting in a waste of drug efficacy.Among various strategies to address the antibacterial dilemma,antibacterial nanomaterials have become a widely recognized emerging method.Zeolite imidazole ester skeleton material-8(ZIF-8)is a metal-organic skeleton material that can grow drugs at connecting nodes,and has become one of the extensively studied antibacterial methods due to its good biocompatibility,structural stability,pH-responsive property,targeted drug delivery,and the ability to reduce the emergence of bacterial drug resistance.At the same time,a large number of studies found that ZIF-8 is favorable for maintaining drug activity and has a potential for clinical antibacterial applications.Therefore,this paper reviewed the antibacterial mechanism,applications and research progress of ZIF-8 in the antibacterial field.It also summarized the challenges and prospects for future development in this field.