高血压分子机制及降压靶点的研究进展

Molecular Mechanisms and Antihypertensive Targets of Hypertension

高血压是导致脑卒中、心肌梗死、心力衰竭和肾衰竭等发生的危险因素,也是导致死亡的主要原因,因此研究高血压的潜在治疗靶点、开发新的抗高血压药尤为重要。现总结近年来关于高血压新治疗靶点的研究进展,包括Elabela/Apelin-APJ轴、序列相似性家族3D蛋白、成纤维细胞生长因子21和血管紧张素Ⅱ1型受体的变构调节,以期为抗高血压药的研究提供新的思路和文献支持。

Hypertension has become one of the most important risk factors,leading to stroke,myocardial infarction,heart failure,kidney failure etc.,and which is also a main cause of death.Therefore,exploring potential therapeutic targets of hypertension and developing new drugs is particularly important to treat hypertension and its comorbidities.This review summarizes recent insights into the potential therapeutic targets,including Elabela/Apelin-APJ axis,family with sequence similarity 3,member D,fibroblast growth factor 21 and the allosteric modulation of angiotensinⅡtype 1 receptor,aiming to provide new insights to improve conventional antihypertensive drugs and develop novel targets for the treatment of hypertension.