血管衰老与老年心血管疾病相关性的研究进展

The Correlation Between Vascular Aging and Elderly Cardiovascular Disease

血管衰老指由于年龄、环境、炎症刺激等因素导致血管结构重构和功能减退的过程,是引起老年人心血管疾病发生的重要因素。现通过对血管衰老的主要发生机制(端粒损耗、线粒体功能障碍、氧化应激、炎症反应、肾素-血管紧张素-醛固酮系统和表观遗传学)进行概述,并针对血管衰老及其机制与老年心血管疾病的相关性进行综述,探讨血管衰老在老年心血管疾病中的作用。展望未来,通过对血管衰老机制中参与老年心血管疾病的关键信号分子、传导通路和调控方式等的更深入研究,为延缓血管衰老、防治老年心血管疾病提供更多可能性。

Vascular aging refers to the process of structural remodeling and functional decline of the vasculature due to age,environment and inflammatory stimuli,which is an important factor contributing to the development of cardiovascular disease in the elderly.In this paper,we explore the role of vascular aging in cardiovascular disease in the elderly by providing an overview of the main mechanisms involved in the occurrence of vascular senescence(telomere depletion,mitochondrial dysfunction,oxidative stress,inflammatory response,renin-angiotensin-aldosterone system and epigenetics)and by providing an overview of vascular aging and its mechanisms in terms of their relevance to cardiovascular disease in the elderly.Looking ahead to the future,through more in-depth research on key signaling molecules,conduction pathways,and regulatory modes involved in the mechanism of vascular aging in elderly cardiovascular disease,more possibilities will be provided for delaying vascular aging and preventing and treating elderly cardiovascular disease.