血管平滑肌细胞线粒体与腹主动脉瘤发生发展的研究进展

Vascular Smooth Muscle Cell Mitochondria and Abdominal Aortic Aneurysm Formation and Development

腹主动脉瘤(AAA)是以腹主动脉壁发生持续性扩张为主要特点的血管疾病,破裂后常导致严重后果。血管平滑肌细胞(VSMCs)是构成血管中膜的重要组成部分,负责调节血管的直径和血流,以维持正常的血液循环和血压。VSMCs线粒体作为VSMCs氧化代谢的中心,在能量产生和细胞代谢中发挥重要作用。近年来,越来越多的研究表明,VSMCs线粒体功能障碍与AAA的发生发展密切相关。现从VSMCs线粒体与氧化应激和炎症、线粒体DNA损伤、线粒体动力学异常和细胞代谢四个方面探讨VSMCs线粒体损伤在AAA发生发展中的研究进展,旨在为AAA未来的治疗和预防提供新的策略。

Abdominal aortic aneurysm(AAA)is a vascular disease characterized by the continuous dilation of the abdominal aorta wall,and its rupture often leads to severe consequences.Vascular smooth muscle cells(VSMCs)are a crucial component of the vascular wall,responsible for regulating vessel diameter and blood flow to maintain normal blood circulation and pressure.The mitochondria of VSMCs serve as the center of cellular oxidative metabolism,playing a significant role in energy production and cell metabolism.In recent years,an increasing amount of research has shown a close association between mitochondrial dysfunction in VSMCs and the development of AAA.This article explores the research progress on VSMCs’mitochondrial damage in the context of AAA development,focusing on four aspects:mitochondrial involvement in oxidative stress and inflammation,mitochondrial DNA damage,mitochondrial dynamics abnormalities,and cell metabolism.The aim is to provide new strategies for the future treatment and prevention of AAA.