氢在口腔炎性疾病中的研究进展

Research advances of hydrogen in oral inflammatory diseases

口腔炎性疾病,涵盖口腔多个亚专业,在牙体、牙周、黏膜等多部位造成患者病痛。这些疾病主要与微生物失衡及机体不适当的免疫反应相关。氢因其抗炎、抗氧化等功能成为研究热点,其治疗效果在全身多种炎性相关疾病模型中已得到证实。在口腔炎性疾病中,氢的研究主要集中在发病率较高的牙周炎,及热点问题——种植体周围炎,同时在特殊条件下的牙周炎、黏膜病、创伤等方面也展开研究。鉴于氢选择性还原剂作用,与口腔炎性疾病的发生、发展高度相关,使其在此方向具有良好的研究和应用前景。现就氢在口腔炎性疾病方向的基础、临床研究及其作用机制进行综述。

Oral inflammatory diseases,involved in multiple oral subspecialties,cause pain in dental pulp,periodontal tissues,mucous membranes and other parts in oral cavities.These diseases are mainly related to microbial imbalance and inappropriate immune response of the organism.Hydrogen has become a research hotspot because of its anti-inflammatory and antioxidant functions,and its therapeutic effect has been confirmed in a variety of systemic inflammatory disease models.Among oral inflammatory diseases,research about hydrogen is mainly focused on periodontitis with high incidence rate and peri-implant inflammation,a current hot issue.At the same time,research has also been conducted on periodontitis,mucosal diseases,and trauma under special conditions.Hydrogen exhibits promising prospects in relevant research and application due to its selective reducing action,which is highly connected with the occurrence and development of oral inflammatory diseases.This review introduces the basic and clinical research of hydrogen in oral inflammatory diseases and also the relevant mechanism.