不同比例血浆与红细胞输注在产后出血患者输血治疗中的应用效果

Application effect of different proportions of plasma and red blood cell infusion in the treatment of postpartum hemorrhage

目的:观察不同比例血浆与红细胞输注在产后出血患者输血治疗中的应用效果。方法:选取2021年4月至2022年7月收治的90例产后出血患者,用随机数字表法分为A组、B组和C组,每组30例。A组予血浆与红细胞0.5∶1比例输注,B组1∶1比例输注,C组1.5∶1比例输注;对比三组血常规指标[血红蛋白(Hb)、血小板(PLT)]、凝血功能指标[纤维蛋白原(FBG)、凝血酶原时间(PT)、活化部分凝血酶时间(APTT)]、输血量及不良反应发生情况。结果:三组输血24h,Hb、PLT水平均较输血前升高,且B组Hb、PLT水平较A组和C组高,差异有统计学意义(P<0.05)。三组输血24h,FBG水平均较输血前升高,PT、APTT较输血前降低,且B组FBG水平较A组和C组高,PT、APTT较A组和C组低,差异有统计学意义(P<0.05)。三组输血量、不良反应总发生率对比差异无统计学意义(P>0.05)。结论:产后出血患者采用血浆与红细胞1∶1比例输注效果较好,可改善凝血功能,且安全性好。

Objective:To observe the application effect of different proportions of plasma and red blood cell(RBC)infusion in the treatment of postpartum hemorrhage.Methods:Ninety patients with postpartum hemorrhage admitted to the hospital from April 2021 to July 2022 were selected and divided into group A,group B and group C with 30 cases in each group by random number table method.Group A received 0.5:1 infusion of plasma to RBC,group B received 1:1 infusion of plasma to RBC,and group C received 1.5:1 infusion of plasma to RBC.Blood routine indexes[hemoglobin(Hb),platelet(PLT)],coagulation function indexes[fibrinogen(FBG),prothrombin time(PT),activated partial thrombin time(APTT)]and the occurrence of adverse reactions were compared among the three groups.Results:The levels of Hb and PLT in the three groups were higher at 24h than those before transfusion,and the levels of Hb and PLT in group B were higher than those in group A and group C,and the difference was statistically significant(P<0.05).After 24h of transfusion,the FBG level of the three groups was higher than that before transfusion,while PT and APTT were lower than those before transfusion,and the FBG level of group B was higher than that in group A and C,while PT and APTT were lower than those in group A and C,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions among the three groups(P>0.05).Conclusion:The 1:1 ratio of plasma to RBC infusion is better for postpartum hemorrhage patients,which can improve coagulation function and has good safety.