脑CT灌注成像参数联合血清FGF-22、AVP水平监测对首发抑郁症患者的诊断价值

Value of CT perfusion imaging parameter combined with detection of serum levels of FGF-22 and AVP in diagnosis of first-episode depressive disorder patients

目的:探讨脑CT灌注成像参数联合血清成纤维细胞生长因子22(FGF-22)、精氨酸加压素(AVP)水平监测在首发抑郁症患者中的诊断价值,以期为临床制定治疗方案提供参考。方法:选取2020年1月—2023年6月于某院就诊的首发抑郁症患者85例为研究组,另选取同期健康体检者85例为对照组,2组均行脑CT灌注成像检查,比较2组研究对象及不同病情严重程度的首发抑郁症患者脑CT灌注成像参数[局部脑血流量(rCBF)、局部脑血容量(rCBV)、达峰时间(TIP)、平均通过时间(MTT)]、血清FGF-22、AVP水平,分析脑CT灌注成像参数、血清FGF-22、AVP水平与病情严重程度的相关性。结果:研究组rCBF、rCBV、血清FGF-22、AVP水平分别为(71.83±5.84)mL/100g/min、(3.78±1.25)mL/100g、(159.52±10.35)ng/mL、(73.54±8.43)ng/L,低于对照组的(82.35±6.59)mL/100g/min、(4.53±1.39)mL/100g、(216.38±14.58)ng/mL、(258.31±18.37)ng/L,TIP、MTT分别为(29.54±2.31)s、(7.12±1.54)s,高于对照组的(24.12±1.85)s、(5.42±1.37)s,差异均有统计学意义(P<0.05)。重度抑郁组rCBF[(65.71±5.54)mL/100g/min]、rCBV[(3.29±0.75)mL/100g]、血清FGF-22[(133.54±10.17)ng/mL]、AVP[(48.25±3.96)ng/L]低于中度抑郁组[(72.15±6.32)mL/100g/min、(3.75±0.93)mL/100g、(154.28±12.85)ng/mL、(68.19±7.25)ng/L]和轻度抑郁组[(75.32±6.74)mL/100g/min、(4.12±1.12)mL/100g、(183.52±15.28)ng/mL、(97.25±10.14)ng/L)],TIP[(33.69±2.76)s]、MTT[(7.80±1.96)s]长于中度抑郁组[(29.36±2.29)s、(7.23±1.72)s)]和轻度抑郁[(27.12±2.15)s、(6.53±1.43)s)],差异有统计学意义(P<0.05)。CT灌注成像参数rCBF、rCBV、血清FGF-22、AVP水平与首发抑郁症病情严重程度呈负相关(r=-0.695、-0.653、-0.742、-0.785,P均<0.05),TIP、MTT与首发抑郁症病情严重程度呈正相关(r=0.728、0.686,P均<0.05)。结论:脑CT灌注成像参数联合血清FGF-22、AVP水平监测可用于首发抑郁症的辅助诊断,为临床评估抑郁程度提供参考。

Objective:To explore the value of CT perfusion imaging(CTP)parameters combined with detection of serum levels of FGF-22 and AVP in the diagnosis of first-episode depressive disorder patients so as to provide reference for clinical treatment.Methods:85 cases of first-episode depressive disorder patients treated in a hospital from January 2020 to June 2023 were selected as a research group,and another 85 healthy adults were recruited as controls.Both the two groups underwent CTP.CTP parameters(rCBF,rCBV,TIP,MTT)and serum levels of FGF-22 and AVP of the two groups and of the first-episode depressive disorder patients with different severity were compared and correlation of CTP parameters,and serum levels of FGF-22 and AVP with severity of the illness was analyzed.Results:The research group’s rCBF,rCBV,and serum levels of FGF-22,AVP were respectively(71.83±5.84)mL/100g/min,(3.78±1.25)mL/100g,(159.52±10.35)ng/mL,and(73.54±8.43)ng/L,lower than the control group’s(82.35±6.59)mL/100g/min,(4.53±1.39)mL/100g,(216.38±14.58)ng/mL,and(258.31±18.37)ng/L;TIP and MTT were respectively(29.54±2.31)s and(7.12±1.54)s,higher than the control group’s(24.12±1.85)s,and(5.42±1.37)s,the differences being significant(P<0.05).The severe depression group’s rCBF,rCBV,and serum levels of FGF-22,AVP were respectively(65.71±5.54)mL/100g/min,(3.29±0.75)mL/100g,(133.54±10.17)ng/mL,and(48.25±3.96)ng/L,lower than the moderate depression group’s(72.15±6.32)mL/100g/min,(3.75±0.93)mL/100g,(154.28±12.85)ng/mL,(68.19±7.25)ng/L,and the mild depression group’s(75.32±6.74)mL/100g/min,(4.12±1.12)mL/100g,(183.52±15.28)ng/mL,(97.25±10.14)ng/L,while TIP and MTT[(33.69±2.76)s,(7.80±1.96)s]were longer than the moderate depression group’s[(29.36±2.29)s,(7.23±1.72)s)]and the mild depression group’s[(27.12±2.15)s,(6.53±1.43)s],the differences being significant(P<0.05).CTP parameters rCBF,rCBV,and serum levels of FGF-22,AVP were negatively correlated with the severity of first-episode depressive disorder(r=-0.695,-0.653,-0.742,-0.785)(all P<0.05);TIP and MTT were positively correlated with the severity of first-episode depressive disorder(r=0.728,0.686)(all P<0.05).Conclusion:CTP parameters combined with detection of serum levels of FGF-22 and AVP may be used as the assistant diagnosis of first-episode depressive disorder,which may provide reference for the clinical assessment of the degree depression.