血清25羟基维生素D、低密度脂蛋白胆固醇与高血压分级的关系

The Relationship among Serum 25-Hydroxyvitamin D,Low-Density Lipoprotein Cholesterol and Hypertension Grading in Hypertensive Patients

【目的】探讨高血压患者血清25羟基维生素D[25-(OH)D]、低密度脂蛋白胆固醇(LDL-C)水平与高血压分级的关系。【方法】在本院就诊的371例高血压患者,根据高血压分级标准分为高血压1级(120例)、高血压2级(124例)、高血压3级(127例),另选取同时期在本院体检的健康者作为对照组(391例)。收集所有受试者一般资料;检测其空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、肌酐(Cr)、高密度脂蛋白胆固醇(HDL-C)、25-(OH)D、LDL-C等指标,并对各指标与25-(OH)D、LDL-C水平进行相关性分析;采用多因素Logistic回归分析影响发生高血压的危险因素。【结果】与对照组比较,高血压组患者体重指数(BMI)、吸烟比例、收缩压(SBP)、舒张压(DBP)、FBG、LDL-C明显升高(P<0.05),25-(OH)D水平明显降低(P<0.05)。高血压患者的BMI、FBG、LDL-C随高血压分级的增加而升高(P<0.05),25-(OH)D水平随高血压分级的增加而降低(P<0.05)。相关分析结果显示,患者BMI、吸烟、SBP、DBP、FBG与血清LDL-C呈正相关(P<0.05),与25-(OH)D水平呈负相关(P<0.05)。多因素Logistic回归分析显示,FBG、LDL-C是高血压发病的独立危险因素(P<0.05),HDL-C、25-(OH)D是高血压发病的保护因素(P<0.05)。【结论】高血压患者25-(OH)D低水平、LDL-C高水平与高血压患者的血压分级密切相关。

【Objective】To explore the relationship among serum 25-hydroxyvitamin D[25-(OH)D]level,low-density lipoprotein cholesterol(LDL-C)level,and the classification of hypertension in hypertensive patients.【Methods】According to the hypertension grading standards,371 hypertensive patients treated in our hospital were divided into grade 1 hypertension(120 cases),grade 2 hypertension(124 cases)and grade 3 hypertension(127 cases).While 391 healthy individuals undergoing physical examinations at our hospital during the same period were selected as the control group.General information of all participants was collected.Fasting blood glucose(FBG),triglycerides(TG),total cholesterol(TC),creatinine(Cr),high-density lipoprotein cholesterol(HDL-C),25-(OH)D,and LDL-C levels were measured.Correlation analysis was conducted between 25-(OH)D and LDL-C levels.Multifactorial logistic regression analysis was used to analyze the risk factors influencing the occurrence of hypertension.【Results】Compared to the control group,the hypertensive group showed significantly higher levels of body mass index(BMI),smoking proportion,systolic blood pressure(SBP),diastolic blood pressure(DBP),FBG,and LDL-C(P<0.05);while the level of 25-(OH)D in the hypertensive group was significantly lower than that in the control group(P<0.05).The BMI,FBG,and LDL-C of hypertensive patients increased with the grade of hypertension(P<0.05),meanwhile the level of 25-(OH)D decreased with the grade of hypertension(P<0.05).The correlation analysis showed that patients'BMI,smoking,SBP,DBP,and FBG were positively correlated with serum LDL-C level(P<0.05)and negatively correlated with 25-(OH)D level(P<0.05).Multifactorial logistic regression analysis showed that FBG and LDL-C were independent risk factors for hypertension(P<0.05),while HDL-C and 25-(OH)D were protective factors against hypertension(P<0.05).【Conclusion】Low level of 25-(OH)D and high level of LDL-C in hypertensive patients are closely related to the blood pressure classification(grades)of hypertension.