直接口服抗凝血药物在骨髓增殖性肿瘤患者血栓防治中的应用

Application of direct oral anticoagulants in the prevention and treatment of thrombosis in patients with myeloproliferative neoplasms

骨髓增殖性肿瘤(MPN)是一组由于造血干细胞增殖异常而引起的疾病,包括骨髓纤维化(MF)、真性红细胞增多症(PV)和原发性血小板增多症(ET)。MPN患者常伴随高血液黏稠度,增加了血栓形成的风险,因此抗凝治疗成为MPN管理中不可或缺的一部分。直接口服抗凝血药物(DOAC)作为一类新型抗凝药物,近年来在血栓防治中的应用逐渐引起关注。本综述将详细探讨DOAC在MPN患者血栓防治中的应用现状、优势与不足、临床研究进展以及未来发展方向。

Myeloproliferative neoplasms(MPN)comprise a group of disorders caused by abnormal proliferation of hematopoietic stem cells,including myelofibrosis(MF),polycythemia vera(PV),and essential thrombocythemia(ET).Patients with MPN often experience increased blood viscosity and an elevated risk of thrombosis.Therefore,anticoagulant therapy has become an indispensable component of MPN management.Direct oral anticoagulants(DOAC),as a novel class of anticoagulants,have gained attention in recent years for their application in thrombosis prevention and treatment.This review will delve into the current status,advantages and disadvantages,clinical research progress,and future directions of DOAC in thrombosis prevention and treatment for MPN patients.