血清S100A11、AIF1水平对高级别宫颈上皮内瘤变的预测价值

Predictive value of serum S100A11 and AIF1 levels in patients with high grade cervical intraepithelial neoplasia

目的研究血清S100钙结合蛋白A11(S100A11)、同种移植炎性因子1(AIF1)对高级别宫颈上皮内瘤变(CIN)患者的预测价值。方法选取2021年1月—2024年1月西北大学第一医院妇产科诊治的CIN患者98例为CIN组,选取同期经病理组织确诊为慢性宫颈炎的患者50例为宫颈炎组,同期医院健康体检的女性50例为健康对照组。采用酶联免疫吸附试验检测血清S100A11、AIF1水平;多因素Logistic回归分析高级别CIN发生的影响因素;受试者工作特征曲线分析血清S100A11、AIF1对高级别CIN发生的预测价值。结果健康对照组、宫颈炎组、CIN组血清S100A11、AIF1水平依次升高,差异均有统计学意义(F/P=369.360/<0.001、269.282/<0.001)。高级别CIN、高危型HPV感染阳性的CIN患者血清S100A11、AIF1水平高于低级别CIN、高危型HPV感染阴性的患者(F/P=95.082/<0.001、92.990/<0.001;t/P=7.903/<0.001、5.392/<0.001);高危HPV感染阳性、血清S100A11水平升高、AIF1升高是影响高级别CIN发生的独立危险因素[OR(95%CI)=1.278(1.149~1.420),1.270(1.114~1.448),1.339(1.079~1.661)];血清S100A11、AIF1及两者联合预测高级别CIN的AUC分别为0.795、0.813、0.906,两者联合优于各自单独预测效能(Z=3.930、3.515,P<0.001)。结论CIN患者血清S100A11、AIF1升高,两者与CIN分级及高危HPV感染有关,两者联合对高级别CIN的发生具有较高的预测价值。

Objective To investigate the predictive value of serum S100 calcium binding protein A11(S100A11)and allogeneic inflammatory factor 1(AIF1)in patients with high grade cervical intraepithelial neoplasia(CIN).Methods Ninety-eight CIN patients(CIN group)treated in Northwest University First Hospital from January 2021 to January 2024 were selected.During the same period,50 patients with chronic cervicitis confirmed by biopsy were selected as the disease control group,and 50 healthy women who underwent physical examinations were selected as the healthy control group.Enzyme linked immunosorbent assay was used to detect serum S100A11 and AIF1 levels in each group.Multivariate Logistic regression analysis was used to identify factors that influence the occurrence of high-grade CIN.The predictive value of serum S100A11 and AIF1 on the occurrence of high-grade CIN was analyzed by analyzing the receiver operating characteristic curve.Results The serum levels of S100A11 and AIF1 in the CIN group were higher than those in the healthy control group and the disease control group,and the differences were statistically significant(F/P=369.360/<0.001,269.282/<0.001).The serum S100A11 and AIF1 levels in CIN patients with high CIN gradeⅡ-Ⅲand high-risk HPV infection positivity were higher than those in CIN gradeⅠand high-risk HPV infection negative patients,and the differences were statistically significant(F/P=95.082/<0.001,92.990/<0.001;t/P=7.903/<0.001,5.392/<0.001).Positive high-risk HPV infection,elevated serum S100A11,and elevated AIF1 were independent risk factors affecting the occurrence of high-grade CIN[OR(95%CI)=1.278(1.149-1.420),1.270(1.114-1.448),1.339(1.079-1.661)].The area under the curve of combined detection of serum S100A11 and AIF1in predicting for high-grade CIN occurrence was 0.906,higher than serum S100A11,AIF1 alone 0.795,0.813,and the difference was statistically significant(Z=3.930,3.515,P<0.001).Conclusion The serum S100A11 and AIF1 levels in CIN patients are elevated,which are related to CIN grading and high-risk HPV infection.The combination of the two has high predictive value for the occurrence of high-grade CIN.