摘要
Hydrogen sulfide(H_(2)S)is a toxic,essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas transmitter.These studies have mainly focused on the production and pharmacological side effects caused by H_(2)S.Therefore,effective strategies to remove H_(2)S has become a key research topic.Furthermore,the development of novel nanoplatforms has provided new tools for the targeted removal of H_(2)S.This paper was performed to review the association between H_(2)S anddisease,relatedH_(2)S inhibitory drugs,aswell as H_(2)S responsive nanoplatforms(HRNs).This review first analyzed the role of H_(2)S in multiple tissues and conditions.Second,common drugs used to eliminate H_(2)S,as well as their potential for combination with anticancer agents,were summarized.Not only the existing studies on HRNs,but also the inhibition H_(2)S combined with different therapeutic methods were both sorted out in this review.Furthermore,this review provided in-depth analysis of the potential of HRNs about treatment or detection in detail.Finally,potential challenges of HRNs were proposed.This study demonstrates the excellent potential of HRNs for biomedical applications.
基金
supported by National Key Research and Development Program of China(contract No.2019YFA0904800)
National Nature Science Foundation of China(32030065,31722033,92049304 to Y.Z.)
Shanghai Sailing Program(contract No.21YF1410300)
Science and Technology Commission of Shanghai Municipality(contract No.10DZ2220500)
The Shanghai Committee of Science and Technology(grant No.11DZ2260600)
Shanghai Frontiers Science Center of Optogenetic Techniques for CellMetabolism(Y.Z.)
Research Unit of New Techniques for Live-cell Metabolic Imaging(Chinese Academy of Medical Sciences,2019-I2M-5-013 to Y.Z.)
the State Key Laboratory of Bioreactor Engineering,the Fundamental Research Funds for the Central Universities.
