精神分裂症患者的治疗依从性影响因素分析及对生活质量和生活能力的影响

Analysis of influencing factors of treatment compliance in patients with schizophrenia and its influence on quality of life and ability of life

目的探究精神分裂症患者治疗依从性的影响因素及对生活质量和生活能力的影响。方法回顾性选取2020年5月至2022年5月芜湖市第四人民医院精神科收治的精神分裂症患者106例,依据Morisky用药依从性问卷(MMAS-8)评分将患者分成高依从性组62例(≥6分)和低依从性组44例(<6分)。采用多元Logistic回归模型分析影响患者治疗依从性的独立危险因素。比较2组患者生活质量[生活质量综合评定问卷(GQOLI-74)]及生活能力[住院精神病人社会功能评定量表(SSFPI)]。结果多元Logistic回归分析结果显示,居住情况、文化程度、用药情况、社会支持程度、一般自我效能感、复发情况、医患关系均为影响精神分裂症患者治疗依从性的独立危险因素。高依从性组GQOLI-74中躯体功能、心理能力、社会功能、物质生活评分均高于低依从性组(P<0.05)。高依从性组SSFPI量表中日常生活能力、活动性和交往情况、社会活动技能评分均高于低依从性组(P<0.05)。结论精神分裂症患者的治疗依从性受到多种因素的影响,低依从性患者的生活质量及生活能力水平也较低,临床应采取针对性措施提高患者治疗依从性,为改善预后奠定基础。

Objective To explore the treatment compliance and quality of life and ability of life of patients with schizophrenics.Methods The data of 106 patients with schizophrenia who were admitted to the Fourth People’sHospital of Wuhu from May 2020 to May 2022 were retrospectively analyzed.According to the score of Morisky 8-item medication adherence questionnaire(MMAS-8),the patients were divided into high compliance group(score≥6,n=62)and low compliance group(score<6,n=44).Multivariate Logistic regression analysis was used to explore independent risk factors affecting patients'treatment compliance.The quality of life(generic quality of life inventory-74[GQOLI-74])and living ability(scale of social function of psychosis inpatients[SSFPI])of patients were compared between the two groups.Results The multivariate logistic regression analysis showed that living conditions,educational level,medication,social support,general self-efficacy,relapse,and doctor-patient relationship were the independent risk factors affecting the treatment compliance of schizophrenia patients.The scores of GQOLI-74 in physical function,psychological ability,social function and material life in the high compliance group were significantly higher than those in the low compliance group(P<0.05).The scores of SSFPI in daily living ability,activity and communication,social activity skills in the high compliance group were significantly higher than those in the low compliance group(P<0.05).Conclusion The treatment compliance of schizophrenic patients is affected by many factors.The patients with low treatment compliance have low quality of life and living ability.Therefore,targeted measures should be taken to improve the treatment compliance of patients,laying a foundation for their good prognosis.