新型恶唑烷酮类抗耐药结核药物的研究进展

New oxazolidinone drugs and perspectives for anti-tuberculosis agents

全球耐药结核病形势严峻,临床中用于治疗耐药结核病的药物选择非常有限,导致了治疗的困难和挑战,开发新型抗结核药物对于耐药结核病的治疗具有关键性的作用。恶唑烷酮类药物及其结构改造物显示出对结核分枝杆菌耐药菌株具有良好的抗菌活性。本文对近期关于恶唑烷酮类药物作用机制、临床前体内外抗结核活性、药动学特点、安全性和临床试验研究进展进行综述。

The global situation of drug-resistant tuberculosis is severe,with limited drug options available for the treatment of drug-resistant tuberculosis,resulting in challenges and difficulties in treatment.The development of new anti-tuberculosis drugs plays a crucial role in the treatment of drug-resistant tuberculosis.Oxazolidinone drugs and their structural derivatives have shown good antibacterial activity against drug-resistant strains of Mycobacterium tuberculosis.This article reviewed recent advances in the understanding of the mechanism of action,preclinical studies on the anti-tuberculosis activity,pharmacokinetic properties,safety,and clinical trials of oxazolidinone drugs.