阿替普酶静脉溶栓治疗急性脑梗死的疗效及对睡眠的影响

The Therapeutic Effect of Intravenous Thrombolysis with Ateplase on Acute Cerebral Infarction and Its Impact on Sleep

目的:探究急性脑梗死患者行阿替普酶静脉溶栓治疗的效果。方法:选取2021年10月至2022年10月山东聊城市人民医院神经内科收治的急性脑梗死患者78例作为研究对象,随机分为观察组和对照组,每组39例。观察组应用阿替普酶静脉溶栓治疗,对照组应用常规治疗。对2组治疗效果、治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、mRS评分、炎症介质水平、氧化应激反应、日常生活活动(ADL)评分、睡眠质量评分进行比较。结果:观察组总有效率(97.44%)高于对照组(76.92%)(P<0.05);治疗后,观察组NIHSS评分、mRS评分,均比对照组低(均P<0.05);治疗后,观察组白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、高敏C反应蛋白(hs-CRP)均优于对照组(均P<0.05);治疗后,观察组超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-px)、丙二醛(MDA),均优于对照组(均P<0.05);治疗后,观察组ADL评分高于对照组(P<0.05),观察组睡眠质量评分优于对照组(P<0.05)。结论:阿替普酶用于急性脑梗死患者临床治疗效果明显,利于其神经功能的改善,且炎症反应与氧化应激明显减轻,一定程度上提高了患者的日常生活活动能力,值得推广。

Objective:To explore the effect of ateplase intravenous thrombolysis on patients with acute cerebral infarction.Methods:A total of 78 patients with acute cerebral infarction admitted to the Neurology Department of Liaocheng People's Hospital in Shandong Province from October 2021 to October 2022 were selected as the study subjects.They were randomly divided into an observation group and a control group,with 39 cases in each group.The observation group received intravenous thrombolysis with ateplase,while the control group received routine treatment.Compare the treatment efficacy,National Institutes of Health Stroke Scale(NIHSS)scores,mRS scores,inflammatory mediator levels,oxidative stress response,Activities of Daily Living(ADL)scores,and sleep quality scores between two groups before and after treatment.Results:The total effective rate of the observation group(97.44%)was higher than that of the control group(76.92%)(P<0.05).After treatment,the NIHSS score and mRS score in the observation group were lower than those in the control group(P s<0.05).After treatment,the observation group received interleukin-1β(IL-1β),Tumor Necrosis Factor-α(TNF-α),the high sensitivity C-reactive protein(hs-CRP)levels were higher than those of the control group(P s<0.05).After treatment,the observation group showed better levels of superoxide dismutase(SOD),glutathione peroxidase(GSH-px),and malondialdehyde(MDA)than the control group(P s<0.05).After treatment,the ADL score of the observation group was higher than that of the control group(P<0.05),and the sleep quality score of the observation group was better than that of the control group(P<0.05).Conclusion:The clinical treatment effect of ateplase on patients with acute cerebral infarction is significant,which is conducive to the improvement of their neurological function,and the inflammatory response and oxidative stress are significantly reduced.To a certain extent,it improves the daily living ability of patients and is worth promoting.