泛素化修饰和SUMO化修饰在电离辐射诱导的DNA损伤修复中的作用机制

Mechanism of ubiquitination modification and SUMOylation modification in DNA damage repair induced by ionizing radiation

泛素和小泛素样修饰物(SUMO)以共价键形式连接到特定的蛋白底物上,进行泛素化修饰或SUMO化修饰,通过调控蛋白质的稳定性、活性、定位或相互作用来影响多种细胞活动,其中包括DNA损伤修复、细胞周期、细胞凋亡和免疫应答等。当细胞受到DNA损伤时,泛素化修饰和SUMO化修饰能够调控相关蛋白质的功能和相互作用,参与到DNA损伤修复和信号传导的过程中。这些修饰作用对于维持基因组的完整性至关重要。近年来,研究发现泛素化修饰和SUMO化修饰在DNA损伤修复中都发挥着重要作用。笔者对这些作用机制进行综述,为深入了解电离辐射诱导的DNA损伤修复机制提供参考。

Ubiquitin and small ubiquitin-like modifier(SUMO)can be covalently attached to specific protein substrates,undergo ubiquitination modification and SUMOylation modification,and affecting their stability,activity,localization or interaction,thus regulating various cell activities,including DNA damage repair,cell cycle,apoptosis and immune responses.When cells experience DNA damage,ubiquitination modification and SUMOylation modification regulate the function and interaction of relevant proteins,thereby participating in the process of DNA damage repair and signal transduction.These modifications are indispensable for maintaining genome integrity.Recent studies have revealed that ubiquitination modification and SUMOylation modification in these repairs.The author reviews these roles,so as to provide a reference for in-depth understanding of the ionizing radiation-induced DNA damage repair mechanism.