乳腺癌患者改良根治术后并发感染的危险因素分析

Risk factors of infection after modified radical mastectomy for breast cancer

目的分析乳腺癌患者改良根治术后并发感染的危险因素。方法病例对照研究。抽取2020年3月至2023年3月郑州大学第一附属医院收治的乳腺癌改良根治术及腋窝淋巴结清扫患者96例,根据术后有无感染分为无感染组和感染组,比较两组间临床特征资料,采用多变量Logistic回归模型评价乳腺癌患者改良根治术后感染的危险因素。结果96例乳腺癌改良根治术患者术后发生感染10例,感染率为10.42%。单因素分析结果显示,无感染组和感染组合并基础疾病、术中出血量、肿瘤TNM分期和置管时间构成比比较差异有统计学意义(P<0.05)。Logistic回归方程分析结果显示,合并糖尿病、术中出血量、肿瘤TNM分期和置管时间是乳腺癌改良根治术后感染的危险因素(OR>1,P<0.05)。结论乳腺癌改良根治术患者术后感染与合并糖尿病、术中出血量、肿瘤TNM分期和置管时间等危险因素有关,需要重点关注存在危险因素的人群,采取相应对策积极预防术后感染的发生,保证手术效果。

Objective To analyze the risk factors of infection after modified radical mastectomy for breast cancer.Methods Conducted as a case-control trail,the study included 96 patients with breast cancer who underwent modified radical mastectomy and axillary lymph node dissection in the First Affiliated Hospital of Zhengzhou University from March 2020 to March 2023.According to the development of infection,the patients were divided into the non-infection group and the infection group.The clinical characteristics of the two groups were compared.Multivariate logistic regression model was used to evaluate the risk factors of infection after modified radical mastectomy for breast cancer.Results Among the 96 patients with breast cancer treated by modified radical mastectomy,10 patients had infection after operation,with an infection rate of 10.42%.Results of univariate analysis showed that there were significant differences in proportions of underlying diseases,intraoperative blood loss volume,tumor-node-metastasis(TNM)stage and indwelling time between the non-infection group and the infection group(P<0.05).The results of logistic regression analysis showed that diabetes mellitus,intraoperative blood loss volume,TNM stage and indwelling time were the risk factors of infection after modified radical mastectomy for breast cancer(OR>1,P<0.05).Conclusions The infection after modified radical mastectomy for breast cancer is related to the risk factors,such as diabetes mellitus,intraoperative blood loss,TNM stage and indwelling time.It is necessary to pay attention to the population with the above risk factors and to take corresponding measures actively to prevent postoperative infection,so as to ensure the effect of surgery.