TG/HDL-C、BNP、CK-MB与超高危动脉粥样硬化性心血管疾病的关系

Correlation of TG/HDL-C,BNP and CK-MB with ultra-high-risk atherosclerotic cardiovascular disease

目的探究三酰甘油/高密度脂蛋白胆固醇(TG/HDL-C)、B型脑钠肽(BNP)、肌酸激酶同工酶(CK-MB)与超高危动脉粥样硬化性心血管疾病的关系。方法回顾性抽取2021年1月至2022年12月驻马店市中心医院收治的动脉粥样硬化性心血管疾病患者82例,依据病情分为超高危组(57例)和非超高危组(25例),另抽取同期体检健康者30例为对照组。检测三组血清TG/HDL-C、BNP和CK-MB水平,比较三组临床资料,应用Logistic回归和Pearson相关性检验分析TG/HDL-C、BNP、CK-MB与超高危动脉粥样硬化性心血管疾病的关系。结果超高危组血清TG、TG/HDL-C、BNP、CK-MB水平,及吸烟者比例、有糖尿病病史者比例、有高血压病史者比例、有调脂药使用史者比例高于非超高危组和对照组(P<0.05),非超高危组上述指标高于对照组(P<0.05)。Logistic回顾分析结果显示,TG/HDL-C、BNP、CK-MB、吸烟、糖尿病病史、高血压病史、调脂药使用史是超高危动脉粥样硬化性心血管疾病的危险因素(P<0.05)。Pearson分析结果显示,超高危动脉粥样硬化性心血管疾病与TG/HDL-C、BNP、CK-MB呈正相关(P<0.05)。结论超高危动脉粥样硬化性心血管疾病受多种因素影响,且与TG/HDL-C、BNP、CK-MB呈正相关。

Objective To investigate the correlation of triglycerides to high-density lipoprotein-cholesterol(TG/HDL-C),brain natriuretic peptide(BNP)and creatine kinase-MB isoenzyme(CK-MB)with ultra-high-risk atherosclerotic cardiovascular disease.Methods Eighty-two patients with atherosclerotic cardiovascular disease treated in Zhumadian Central Hospital from January 2021 to December 2022 were selected retrospectively,and they were divided into the ultra-high-risk group(57 cases)and the non-ultra-high-risk group(25 cases)according to the state of illness;and another 30 healthy individuals who underwent physical examination during the same period were selected as the control group.The serum levels of TG/HDL-C,BNP and CK-MB in the three groups were detected.The clinical data of the three groups were compared.The correlations of TG/HDL-C,BNP and CK-MB with ultra-high-risk atherosclerotic cardiovascular disease were analyzed by logistic regression analysis and Pearson correlation test.Results The ultra-high-risk group had higher levels of TG,TG/HDL-C,BNP and CK-MB,and had higher proportions of smokers,diabetes mellitus,hypertension and lipid-regulating drugs compared with the non-ultra-high-risk group and the control group(P<0.05);and the above indexes of the non-ultra-high-risk group were higher than those of the control group(P<0.05).Results of logistic regression analysis showed that TG/HDL-C,BNP,CK-MB,history of smoking,history of diabetes mellitus,history of hypertension,and usage of lipid-regulating drug were risk factors for ultra-high-risk atherosclerotic cardiovascular disease(P<0.05).Results of Pearson analysis showed that ultra-high-risk atherosclerotic cardiovascular disease was positively correlated with TG/HDL-C,BNP and CK-MB(P<0.05).Conclusions Ultra-high-risk atherosclerotic cardiovascular disease can be affected by various factors,and is positively correlated with TG/HDL-C,BNP and CK-MB.