低钙腹膜透析液透析治疗慢性肾衰竭的效果观察

Observation of application effect of low calcium peritoneal dialysis solution in patients with chronic renal failure

目的分析低钙腹膜透析液透析治疗在慢性肾衰竭患者中的应用效果。方法队列对照研究。抽取2021年7月至2022年12月郑州市第三人民医院收治的慢性肾衰竭患者92例,按随机数字表法分为对照组和观察组,每组46例。对照组予以标准钙腹膜透析液透析治疗,观察组予以低钙腹膜透析液透析治疗。对比两组临床疗效、钙磷代谢指标(血磷、钙磷乘积、血钙)、肾功能[尿素氮(BUN)、血肌酐(SCr)]水平、残余肾功能水平、炎症因子[白细胞介素-18(IL-18)、尿肾损伤分子1(KIM-1)]水平及并发症发生率。结果观察组总有效率(95.65%,44/46)高于对照组(76.09%,35/46),P<0.05。治疗后,观察组血磷、钙磷乘积、血钙水平均低于对照组(P均<0.05);治疗后,观察组SCr、BUN水平均低于对照组(P均<0.05)。治疗6个月后,两组残余肾功能水平比较差异未见统计学意义(P>0.05);治疗1年后,观察组残余肾功能水平高于对照组(P<0.05)。治疗后,观察组KIM-1、IL-18水平低于对照组(P<0.05)。两组并发症发生率比较差异未见统计学意义(P>0.05)。结论慢性肾衰竭患者采用低钙腹膜透析液透析治疗的疗效确切,能够改善其钙磷代谢指标,减轻炎症反应和肾功能损伤,延缓残余肾功能减退,安全可靠。

Objective To analyze the application effect of low calcium peritoneal dialysis solution in patients with chronic renal failure.Methods This study was a cohort controlled trial.Ninety-two patients with chronic renal failure treated in Zhengzhou Third People’s Hospital from July 2021 to December 2022 were selected,and they were divided into control group and observation group by random number table method,with 46 cases in each group.The control group received standard calcium peritoneal dialysis treatment,while the observation group received low calcium peritoneal dialysis treatment.The clinical efficacy,calcium phosphorus metabolism indicators(blood phosphorus,calcium phosphorus product,blood calcium),renal function assessed by blood urea nitrogen(BUN)and serum creatinine(SCr),residual renal function levels,inflammatory factors levels,including interleukin-18(IL-18)and urinary kidney injury molecule 1(KIM-1),and incidence of complications were compared between the two groups.Results The total effective rate of the observation group was 95.65%(44/46),which was higher than the 76.09%(35/46)of the control group(P<0.05).After treatment,the blood phosphorus,calcium phosphorus product,and blood calcium levels in the observation group were lower than those in the control group(all P<0.05).After treatment,the levels of SCr and BUN in the observation group were lower than those in the control group(all P<0.05).After 6 months of treatment,there was no significant difference in residual renal function levels between the two groups(P>0.05);after 1 year of treatment,the residual renal function levels in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of KIM-1 and IL-18 in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusions The use of low calcium peritoneal dialysis solution has a definite therapeutic effect on chronic renal failure patients;it can improve calcium and phosphorus metabolism indicators,reduce inflammatory reactions and renal function damage,and delay residual renal function decline,which is safe and reliable.