基于中西医病证结合特点的中风后抑郁动物模型评价分析

Evaluation and Analysis of Animal Models of Post-Stroke Depression Based on the Characteristics of Disease-Syndrome Combination in Traditional Chinese and Western Medicine

基于中风后抑郁(PSD)中西医临床诊断标准,总结和归纳PSD动物模型的造模方法与优缺点,并分析其与中西医临床病证特点的吻合度。发现PSD动物模型的造模方法以复合型方法为主,其中中西医临床特点吻合度最高的模型为大脑中动脉缺血再灌注(MCAO)+孤养+慢性不可预见温和刺激(CUMS)法,能够部分模拟出瘀血、痰瘀互结、肝气郁结、等证候。然而当前PSD造模方法多为脑卒中和抑郁症造模方法的单纯结合,尚无一体性的PSD造模法,同时由于缺少PSD中西医临床诊断标准与模型评价标准,其造模方法仍以抑郁症诊断及模型评价标准为主,且偏向于现代医学模型,中医病证模型较少,因此在PSD中医学临床诊断及模型评价方面存在一定误差。完善PSD中西医临床诊断及模型评价标准,并且制备符合中医临床特点的PSD动物模型,对探究PSD发病机制及治疗方法有着重大的研究意义。

Based on the clinical diagnostic criteria of traditional Chinese medicine(TCM)and western medicine for post-stroke depression(PSD),the present study summarized the advantages and disadvantages of animal models of PSD,and analyzed the coincidence between PSD and the clinical disease-syndrome characteristics in TCM and western medicine.The results showed that the animal models of PSD were mainly based on mixed methods,and the model with the highest coincidence of clinical characteristics in TCM and western medicine was induced by middle cerebral artery occlusion(MCAO)+neonatal isolation+chronic unpredictable mild stress(CUMS),which could partially simulate the syndrome,such as Xueyu(血痧),Tanyujiaojie(痰瘀交结),and Ganqiyujie(肝气郁结).However,the current modeling methods for PSD are dominated by the pure combination of modeling methods for cerebral apoplexy and depression,and there is a lack of a unified PSD modeling method.Meanwhile,due to the lack of clinical diagnostic criteria and model evaluation criteria for PSD in TCM and western medicine,the modeling methods are still mainly based on diagnostic and model evaluation criteria for depression.Additionally,the models incline towards modern medicine,and those for TCM disease-syndrome combination are few.Therefore,there are some errors in clinical diagnosis and model evaluation of PSD.It is of great significance to improve the clinical diagnosis and model evaluation criteria for PSD in TCM and western medicine and prepare PSD animal models conforming to the clinical characteristics of TCM for the exploration of the pathogenesis and treatment of PSD.