晚期慢性肾脏病患者骨质疏松症的治疗研究进展

Research progress on the treatment of osteoporosis in patients with advanced chronic kidney disease

骨质疏松症是慢性肾脏病(CKD)患者常见的并发症之一,严重影响患者的生存质量及增加病死率。抗骨质疏松药物根据作用机理不同,主要分为骨吸收抑制剂和骨形成促进剂两大类。晚期CKD患者应用抗骨质疏松药物时更容易出现不良反应、增加CKD进展风险。本文综述了晚期CKD患者骨质疏松症的治疗研究进展,以期为临床工作提供帮助。

Osteoporosis is one of the common complications of patients with chronic kidney disease (CKD), and can seriously affect the patients’ quality of life and increase the mortality. According to their mechanisms of action, the anti-osteoporosis drugs are mainly divided into bone resorption inhibitors and osteoanabolic agents. Patients with advanced CKD are more likely to experience adverse effects of anti-osteoporosis drugs, and may have an increased risk of CKD progression. This article reviewed the progress of research on the treatment of osteoporosis in patients with advanced CKD, aiming to provide assistance for clinical work.