铁死亡在骨肉瘤中的分子机制及相关治疗的研究进展

Research progress on the molecular mechanism and related treatments of ferroptosis in osteosarcoma

骨肉瘤作为常见的原发恶性骨肿瘤之一,因其较差的预后及较单一的治疗方式,使得目前临床对骨肉瘤患者的治疗已达到瓶颈期。然而,越来越多的研究发现铁死亡作为一种新型的细胞死亡方式,或可在骨肉瘤的治疗中发挥重要作用。近年来,随着对铁死亡相关机制及分子通路研究的愈加深入,其在骨肉瘤中的特异性治疗策略也相继得以验证,这有望为骨肉瘤患者的临床治疗提供新思路。

Osteosarcoma is one of the most common primary malignant bone tumors,which has reached a"bottleneck"in the current clinical treatment of patients with osteosarcoma due to its poor prognosis and lack of therapeutic modalities.Recently,more and more researches have found that ferroptosis,as a novel cell death modality,may play an important role in osteosarcoma treatment.In recent years,with more in-depth studies on the mechanisms and molecular pathways related to ferroptosis,its specific therapeutic strategies in osteosarcoma have also been validated,which is expected to provide new ideas for the clinical treatment of osteosarcoma patients.