化痰通络汤对急性脑梗死血管内治疗再灌注临床研究

Clinical Study on Huatan Tongluo Decoction for Intravascular Treatment of Acute Cerebral Infarction and Reperfusion

目的:观察化痰通络汤对急性脑梗死血管内治疗再灌注情况。方法:选取2022年8月—2023年9月阳江市中医医院收治的60例急性脑梗死血管内治疗患者。根据随机数表法将其分为对照组与干预组,各30例。对照组给予常规治疗,干预组在对照组基础上给予化痰通络汤。比较两组治疗前后血脂指标、相关指标、神经功能、中医症候积分,临床疗效及安全性。结果:治疗后,干预组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,干预组纤维蛋白原(FIB)、D-二聚体(D-D)、C反应蛋白(CRP)水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,干预组美国国立卫生研究院卒中量表(NIHSS)评分、中医症候积分均低于对照组,差异有统计学意义(P<0.05)。干预组总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗期间均未发生严重不良反应。结论:化痰通络汤用于急性脑梗死血管内治疗患者效果显著,能降低患者血脂、FBI、D-D、CRP水平。

Objective:To observe the reperfusion of Huatan Tongluo Decoction for intravascular treatment of acute cerebral infarction.Method:A total of 60 patients with acute cerebral infarction who received intravascular treatment in Yangjiang Hospital of Traditional Chinese Medicine from August 2022 to September 2023 were selected.They were divided into control group and intervention group according to random number table method,with 30 cases in each group.The control group was given routine treatment,intervention group was given Huatan Tongluo Decoction on the basis of control group.Blood lipid indexes,related indexes,neurological function,traditional Chinese medicine syndrome scores before and after treatment,clinical efficacy and safety were compared between the two groups.Result:After treatment,the levels of total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)in the intervention group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of fibrinogen(FIB),D-dimer(D-D),C-reactive protein(CRP)in the intervention group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the national institutes of health stroke scale(NIHSS)score and traditional Chinese medicine syndrome score in the intervention group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of the intervention group was higher than that of the control group,and the difference was statistically significant(P<0.05).No serious adverse reactions occurred in both groups during treatment.Conclusion:Huatan Tongluo Decoction is effective in the intravascular treatment of patients with acute cerebral infarction,and can reduce the levels of blood lipid,FBI,D-D and CRP.