沙库巴曲缬沙坦联合美托洛尔治疗慢性心力衰竭的临床效果

Clinical Efficacy of Sacubitril Valsartan Combined with Metoprolol in Chronic Heart Failure

目的:探讨沙库巴曲缬沙坦联合美托洛尔在慢性心力衰竭(CHF)患者中的应用效果。方法:选取2022年6月—2023年6月石阡县人民医院收治的60例CHF患者作为研究对象,按随机数表法分两组,各30例。对照组给予美托洛尔治疗,观察组在对照组基础上加用沙库巴曲缬沙坦治疗。比较两组临床疗效、血管内皮功能、心功能指标、血清学指标及不良反应发生率。结果:观察组治疗有效率为93.33%,高于对照组的73.33%,差异有统计学意义(P<0.05)。治疗后,观察组左心射血分数(LVEF)、每搏输出量(SV)、一氧化氮(NO)高于对照组,左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)、内皮素1(ET-1)、B型脑利钠肽前体(NT-proBNP)、超敏C反应蛋白(hs-CRP)、血管紧张素Ⅱ(AngⅡ)、肌酶激酶(CK)低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:沙库巴曲缬沙坦联合美托洛尔可以增强CHF治疗效果,加快心功能改善与心衰症状缓解,安全性高。

Objective:To investigate the effect of Sacubitril Valsartan combined with Metoprolol in patients with chronic heart failure(CHF).Method:A total of 60 patients with CHF admitted to Shiqian County People's Hospital from June 2022 to June 2023 were selected as the study objects and divided into two groups according to random number table method,with 30 cases in each group.The control group was treated with Metoprolol,and the observation group was treated with Sacubitril Valsartan on the basis of control group.The clinical efficacy,vascular endothelial function,cardiac function index,serological index and incidence of adverse reactions were compared between the two groups.Result:The effective rate of observation group was 93.33%,which was higher than 73.33%of control group,and the difference was statistically significant(P<0.05).After treatment,left ventricular ejection fraction(LVEF),stroke volume(SV),and nitric oxide(NO)in observation group were higher than those in control group,left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),endothelin-1(ET-1),N-terminal pro-brain natriuretic peptide(NT-proBNP),hypersensitive C-reactive protein(hs-CRP),angiotensin Ⅱ(AngⅡ)levels,and creatine kinase(CK)were lower than those of control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Sacubitril Valsartan combined with Metoprolol can enhance the treatment effect of CHF,accelerate the improvement of heart function and the relief of heart failure symptoms,with high safety.