原发性干燥综合征合并抑郁症发病相关机制研究进展

Research Progress on the Pathogenesis of Primary Sjogren's Syndrome Complicated with Depression

原发性干燥综合征(primary Sj?gren’s syndrome,PSS)是一种以侵犯外分泌腺为特征的慢性炎症性结缔组织病,好发于女性,可累及多个脏器系统,如呼吸系统、血液系统、神经系统、皮肤、肌肉、骨骼等,其突出症状为口干、眼干。临床上PSS合并抑郁症的患者较多见,抑郁症的发生严重影响着PSS患者的身心健康和生活质量,给家庭、社会带来十分沉重的负担,被越来越多地关注,随着研究的深入,PSS患者并发抑郁症的发病机制复杂多样。本文分别从躯体-社会-心理、免疫系统、神经内分泌系统及认知功能方面,较为全面地分析PSS合并抑郁症的发病相关机制,以期改善PSS合并抑郁症患者的治疗手段及生活质量。

Primary Sjögren's syndrome(PSS)is a chronic inflammatory connective tissue disease characterized by invading exocrine gland,it is more common in female,it can involve multiple organ systems,such as respiratory system,blood system,nervous system,skin,muscle,bone,etc,its prominent symptoms are dry mouth,dry eyes.PSS complicated with depression is more common,the occurrence of depression seriously affects the physical and mental health and quality of life of PSS patients,and brings a very heavy burden to the family and society,it is more and more attention,with the deepening of the research,the pathogenesis of depression in PSS patients is complex and diverse.This paper comprehensively analyzed the pathogenesis of PSS complicated with depression from the aspects of somatic-social-psychological,immune system,neuroendocrine system and cognitive function,in order to improve the treatment methods and quality of life of PSS complicated with depression patients.