沙丁胺醇联合布地奈德雾化吸入治疗慢性阻塞性肺疾病的临床效果

Clinical Effect of Salbutamol Combined with Budesonide Aerosol Inhalation in the Treatment of Chronic Obstructive Pulmonary Disease

目的:研究沙丁胺醇联合布地奈德雾化吸入治疗慢性阻塞性肺疾病(COPD)的临床效果。方法:选取2021年4月—2023年3月滁州市第一人民医院收治的82例COPD患者作为研究对象,按照随机抽签法分为观察组(采取沙丁胺醇联合布地奈德雾化吸入治疗)和对照组(采取沙丁胺醇雾化吸入治疗),各41例。比较两组临床疗效、肺功能指标、动脉血气指标、气道功能指标及安全性。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组肺功能指标、动脉血气指标、气道功能指标比较,差异无统计学意义(P>0.05);治疗后,两组第1秒用力呼气容积(FEV_(1))、FEV_(1)/用力肺活量(FVC)百分比(FEV_(1)/FVC%)、最大呼气流量(PEF)、用力呼出75%肺活量时的平均呼气流速(MEF75)、氧合指数、动脉血氧分压(PaO_(2))、比气道传导率(sGAW)高于治疗前,且观察组高于对照组,两组动脉二氧化碳分压(PaCO_(2))、气道阻力(RAW)、比气道阻力(sRAW)低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:沙丁胺醇联合布地奈德雾化吸入治疗COPD效果显著,能改善患者的肺功能和动脉血气指标,提高通气质量,且不会增加不良反应发生率。

Objective:To study the clinical effect of Salbutamol combined with Budesonide aerosol inhalation in the treatment of chronic obstructive pulmonary disease(COPD).Method:A total of 82 patients with COPD admitted to Chuzhou First People's Hospital from April 2021 to March 2023 were selected as the study objects,and they were divided into the observation group(Salbutamol combined with Budesonide aerosol inhalation treatment)and the control group(Salbutamol aerosol inhalation treatment)according to random drawing method,with 41 cases in each group.The clinical efficacy,pulmonary function index,arterial blood gas indexes,airway function indexes and safety of the two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in pulmonary function indexes,arterial blood gas indexes and airway function indexes between two groups(P>0.05).After treatment,the forced expiratory volume in one second(FEV_(1)),FEV_(1)/forced vital capacity(FVC)percentage(FEV_(1)/FVC%),peak expiratory flow(PEF),mean expiratory flow rate(MEF75),oxygenation index,arterial partial pressure of oxygen(PaO_(2))and specific airway conductivity(sGAW)in two groups were higher than those before treatment,and those in the observation group were higher than those in the control group,the arterial partial pressure of carbon dioxide(PaCO_(2)),airway resistance(RAW)and specific airway resistance(sRAW)in two groups were lower than those before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).Conclusion:Salbutamol combined with Budesonide aerosol inhalation has a significant effect in the treatment of COPD,which can improve lung function and arterial blood gas indexes of patients,improve ventilation quality,and do not increase the incidence of adverse reactions.