钯催化的碳(sp^(3))-硅键转化实现碳(sp^(3))-碳(sp^(2))偶联制备三氟丙基(杂)芳烃

Palladium-Catalyzed C(sp^(3))—Si Bonds Transformation for Construct-ing Trifluoropropyl(Hetero)arenes through C(sp^(3))—C(sp^(2))Cross-Coupling Reactions

使用商业可得的三烷氧基三氟丙基硅试剂,通过钯催化的碳(sp^(3))-硅键转化实现了C(sp^(3))—C(sp^(2))偶联反应.该偶联反应方法具有良好的官能团兼容性,可以有效制备一系列含多种官能团的三氟丙基(杂)芳烃.氟离子添加剂和双膦配体的脂肪链的调节对于提高反应效率有重要的作用.

Palladium-catalyzed C(sp^(3))—Si bonds transformation of commercially available polyalkoxy trifluorosilane reagents has been developed through C(sp^(3))—C(sp^(2))cross-coupling reactions.This Hiyama cross-coupling reaction shows good functional group tolerance and provides a series of trifluoropropyl(hetero)arenes.The fluoride source and alkyl tether of bisphosphine ligand play important roles in improving yields.