摘要
从海南民间药用植物土坛树树皮中分离得到2个新的高度氧化的杜松烷型倍半萜类化合物alansalene A(1)和2,7-二羟基-4-异丙基-1-甲基-6-萘醛(5)以及5个已知的同系物,通过NMR、HR-ESI-MS等多种现代波谱技术确定了其化学结构.体外抗炎活性显示,化合物alangene D(2)具有突出的抗炎活性,其IC_(50)=(2.98±0.11)μmol/L强于阳性对照药物地塞米松[IC_(50)=(39.62±0.12)μmol/L].体外α-葡萄糖苷酶抑制活性显示,化合物alangene F(3)和2,7-二羟基-4-异丙基-6-甲基萘-1-甲醛(6)表现出强的α-葡萄糖苷酶抑制活性,其IC_(50)值为分别为(111.85±1.80)和(18.55±0.68)μmol/L[阳性对照阿卡波糖IC_(50)=(478.75±27.14)μmol/L].
Two new highly oxidized cadinane sesquiterpenes of alansalene A(1)and 2,7-dihydroxy-4-isopropyl-1-methyl-6-naphthaldehyde(5),and five known analogues were isolated from the barks of Alangium salviifolium,which is a folk medicinal plant in Hainan.The structures were elucidated by spectroscopic methods(1D and 2D NMR,HR-ESI-MS).Compound alangene D(2)exhibited stronger anti-inflammatory activity in vitro with IC_(50) value of(2.98±0.11)μmol/L to that of dexamethasone[IC_(50)=(39.62±0.12)μmol/L].Alangene F(3)and 2,7-dihydroxy-4-isopropyl-6-methylnaphthalene-1-carbaldehyde(6)displayed potentialα-glucosidase inhibitory activities with IC_(50) values of(111.85±1.80)and(18.55±0.68)μmol/L,respectively,which were stronger than that of acarbose[IC_(50)=(478.75±27.14)μmol/L].
作者
魏艳梅
余章昕
杜怡益
王平淑
岑福凌
李小宝
陈光英
Wei Yanmei;Yu Zhangxin;Du Yiyi;Wang Pingshu;Cen Fuling;Li Xiaobao;Chen Guangying(Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education,Hainan Normal University,Haikou 571158;Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2024年第4期1363-1367,共5页
Chinese Journal of Organic Chemistry
基金
海南省重点研发项目(Nos.ZDYF2022SHFZ286,ZDYF2021SHFZ072)
国家自然科学基金(No.21662012)
海南省院士创新平台(No.YSPTZX202030)
中央引导地方科技发展专项(No.ZY2022HN08)
海南师范大学“大学生创新创业训练计划”(No.202311658005)资助项目。
关键词
土坛树
高度氧化
倍半萜
抗炎
α-葡萄糖苷酶抑制
Alangium salviifolium
highly oxidization
sesquiterpene
anti-inflammatory
α-glucosidase inhibitory
