硼促进甘氨酸衍生物的电化学C(sp^(2))—H溴化反应

Electrochemical C(sp^(2))-H Bromination of Glycine Derivatives Enabled by Boron

报道了一种室温条件下甘氨酸衍生物的电化学芳烃C(sp^(2))—H键溴化方法.在温和反应条件下,以四丁基溴化铵或四丁基三溴化铵为溴源和电解质,顺利地合成了一系列C(sp^(2))—H键溴化的甘氨酰胺、甘氨酸酯和二肽类化合物,收率最高可达95%.与传统方法相比,该方法具有底物范围广泛、官能团兼容性好、操作方便、无需外加氧化剂和金属催化剂等特点,更加符合绿色化学和环境保护的要求.

A method for the electrochemical arene C(sp^(2))—H bromination of glycine derivatives at room temperature is reported.Under mild reaction conditions,a series of brominated N-aryl glycine amides,N-aryl glycine esters,and dipeptide at aromatic C(sp^(2))—H bonds were smoothly synthesized using tetrabutylammonium bromide or tetrabutylammonium tribromide as Br sources and electrolytes with up to 95%yield.Compared with traditional methods,this methodology features broad substrate scope,good functional group compatibility,easy operation,without using additional oxidants and metal catalysts,thus much conforms to the requirement of green chemistry and environmental protection.