基于WOS数据库的骨质疏松症与肠道菌群研究现状及热点分析

Current status and hotspot analysis of research on osteoporosis and intestinal flora based on Web of Science database

目的 基于Web of Science(WOS)数据库分析骨质疏松症与肠道菌群研究的相关文献,明确其研究热点与趋势,为日后相关研究提供参考。方法 通过对WOS核心数据库进行主题词字段检索,时间设置为建库至2022年,于2023年5月9日完成检索;应用文献计量学方法及CiteSpace软件,对国家/地区、机构、期刊及关键词等文献特征进行统计分析。结果 共获取有效文献376篇,论文247篇,综述129篇。研究起始年限为1998年,研究数量整体保持不断增长,尤其2019年以后的文献数量增幅最为显著。研究国家主要分布于亚洲、美国与欧洲等地区,研究机构以高校为主。刊登文献数量排名前10位的期刊出版国为美国与瑞士;《Nutrients》杂志(16篇,4.26%)的载文量最多,《Bone》杂志中文献篇均被引用频次最高,为36.17次。文献被引频次排名前10位的研究内容中,有4篇涉及“应用益生菌防治绝经后骨质流失”,且标题为“性类固醇缺乏相关的骨质流失是依赖于微生物群和可被益生菌防治”被引频次最多,为96次。研究热点包括骨质疏松症与肠道菌群的相关性研究(关键词:矿物密度、健康、骨密度、骨质丢失等),以及重点探讨肠道菌群防治骨质疏松症的潜在靶点(关键词:肠道通透性、肠-骨轴、链式脂肪酸等)。研究趋势为髋骨骨折。结论 近20年间,骨质疏松症与肠道菌群研究的关注度持续在提升。后续建议应基于肠道菌群调控机制与治疗靶点,开展多中心、大型的临床研究加以验证与推广。

Objective To analyze the literatures related to osteoporosis and intestinal flora research based on Web of Science database,to clarify its research hotspots and trends,and to provide references for related research in future.Methods The Web of Science Core Collection database was searched by subject term fields.The time was set from the establishment of the database to 2022,and the search was completed on May 9,2023.The bibliometric method and CiteSpace software were employed to statistically analyze the literature characteristics such as country/region,institution,journal and keywords.Results A total of 376 valid papers were obtained,including 247 papers and 129 reviews.The study started in 1998,and the overall number of studies kept growing,especially the most significant increase in the number of literatures after 2019.The research countries were mainly distributed in Asia,the United States and Europe,and the research institutions were mainly universities.The countries with the top 10 journals with published literatures were the United States and Switzerland.Nutrients(16 articles,4.26%)published the largest number of articles,and Bone had the highest average citation frequency,with 36.17 times.Four of the top 10 cited studies were related to the role of probiotics in the prevention and treatment of postmenopausal bone loss,with the title of“sex steroid deficiency-associated bone lossis microbiota dependent and prevented by probiotics”being cited the most frequently and the number of citations being 96.Hot topics of research included the correlation between osteoporosis and gut flora(keywords:mineral density,health,bone density,bone loss,etc.)and the focus on potential targets of gut flora to prevent osteoporosis(keywords:gut permeability,gut-bone axis,short-chain fatty acids,etc.).The research trend was hip fracture.Conclusion The attention of osteoporosis and intestinal flora research has continued to increaseduring the past 20 years.It is recommended that multi-center and large-scale clinical studies should be conducted to validate and promote the relevant intestinal flora regulatory mechanisms and therapeutic targets.