孙氏头针腹针联合盐酸多奈哌齐治疗阿尔茨海默病的临床观察

Clinical observation on treatment of Alzheimer's disease with Sun's scalp-abdominal acupuncture combined with donepezil hydrochloride

目的:观察孙氏头针腹针联合盐酸多奈哌齐对阿尔茨海默病(AD)患者认知和生活能力的影响,评价其临床疗效。方法:收集AD患者60例,随机分为对照组与观察组,每组30例。对照组患者口服盐酸多奈哌齐,每日1次;观察组患者在对照组基础上行孙氏头针、腹针电针治疗,每日1次,每次30 min。4周为一个疗程,两组均连续治疗2个疗程。治疗前后进行简易精神状态检查量表(MMSE)、AD评定量表-认知部分(ADAS-Cog)及日常生活活动能力量表(ADL)评定。计算两组的临床疗效指数,进行安全性评价。结果:治疗后,两组患者的MMSE、ADL评分较治疗前升高(P<0.05),ADAS-Cog评分较治疗前降低(P<0.05);与对照组比较,观察组患者的MMSE、ADL评分升高(P<0.05),ADAS-Cog评分降低(P<0.05);观察组总有效率(26/30,86.67%)高于对照组(26/30,76.67%,P<0.05)。两组患者在治疗期间均未出现不良反应。结论:电针孙氏头针腹针联合盐酸多奈哌齐可有效改善AD患者的认知能力和日常生活能力,疗效优于单纯口服盐酸多奈哌齐。

Objective To observe the effect of scalp-abdominal acupuncture combined with donepezil hydrochloride on cognition and life ability of patients with Alzheimer's disease(AD),so as to evaluate its clinical efficacy.Methods Sixty AD patients were collected and randomly divided into control group(30 cases) and observation group(30 cases).Patients in the control group were treated with oral donepezil hydrochloride(5 mg,once daily).Patients in the observation group were treated with scalp-abdominal acupuncture at Baihui(GV20),Yintang(GV24+),Sishencong(EX-HN1),“emotional area”,Shenting(GV24),“abdominal area 1”“abdominal area 8”,and bilateral Fengchi(GB20),Taixi(KI3),Xuanzhong(GB39),Zusanli(ST36) on the basis of control group,and electroacupuncture(10 Hz/50 Hz,0.5 to 5.0 mA) was applied to EX-HN1,“emotional area”“abdominal area 1” and “abdominal area 8”,once daily,30 min each time.Four weeks as a course of treatment,both the two groups were treated for two consecutive courses.Before and after treatment,the mini-mental state examination(MMSE),AD assessmennt scale-cognitive subscale(ADAS-Cog) and activity of daily living scale(ADL) were evaluated.The clinical efficacy index was calculated and safety was evaluated.Results After treatment,the MMSE and ADL scores were higher(P<0.05) and the ADAS-Cog score was lower(P<0.05) than those before treatment in both groups.Compared with the control group,the MMSE and ADL scores were increased(P<0.05) and ADAS-Cog score was decreased(P<0.05) in the observation group.The total effective rate of the observation group(26/30,86.67%) was higher(P<0.05) than that of the control group(23/30,76.67%).No adverse reactions occurred in both groups during the treatment.Conclusion Scalp-abdominal acupuncture combined with donepezil hydrochloride can effectively improve the cognitive ability and daily living ability of AD patients,and the efficacy is better than that of oral donepezil hydrochloride alone.