基于大脑海马区参与疼痛探讨其在针刺镇痛中的作用

Role of Hippocampus in Pain Regulation and Its Involvementin Acupuncture Analgesia

一直以来,疼痛都是备受全世界关注的公共卫生问题,亟待解决。针刺是良好的镇痛疗法,具有整体调节的优势,针刺并非只改善疼痛患者某一方面的功能障碍,而对疼痛感觉、情绪、认知及社交等维度具有综合性影响。大脑是针刺镇痛过程中的最高级中枢,其中与学习、记忆以及情绪调节有关的海马参与疼痛多维度的形成与调节。随着针刺镇痛的脑机制研究逐步深入,针刺通过多角度调控海马以镇痛的机制值得关注,并有望成为解开针刺镇痛脑机制奥秘的落脚点,因此本研究围绕海马在疼痛中的作用及其介导针刺镇痛的研究展开探讨。

Pain has always been a major public health concern worldwide and is in urgent need of resolution.Acupuncture is a well-established method for pain relief,with the advantage of comprehensive regulation.Acupuncture not only improves specific functional impairments in pain patients but also has a comprehensive impact on pain perception,emotions,cognition,and social aspects.The brain serves as the highest central nervous system in the process of acupuncture analgesia,with the hippocampus,involved in learning,memory,and emotional regulation,participating in the multidimensional formation and regulation of pain.As research on the brain mechanisms of acupuncture analgesia deepens,the mechanism by which acupuncture regulates the hippocampus to alleviate pain from multiple perspectives deserves attention and may become a focal point for unraveling the mysteries of acupuncture analgesia mechanisms.Therefore,this study reviewed and discussed the role of the hippocampus in pain and its mediation of acupuncture analgesia,providing a reference for further research.