靳三针调神针法治疗帕金森病轻中度抑郁的临床研究

Clinical Study of JIN’s Three-Needle Regulating Shen Acupuncture in Treatment of Mild-to-Moderate Parkinson's Disease Depression

目的:观察靳三针调神针法治疗帕金森病轻中度抑郁(PDD)的临床疗效及安全性。方法:将72例符合纳排标准的患者以随机数字表法分为两组,每组36例。治疗组采用靳三针调神针法联合基础治疗,对照组仅采用基础治疗。本研究对比治疗前、后汉密尔顿抑郁量表-17项(HAMD-17)、统一帕金森病量表-第3部分(UPDRS-Ⅲ)、39项帕金森病生活质量量表(PDQ-39)、帕金森病睡眠量表(PDSS)和治疗后第30天PDQ-39评分,并且记录不良事件。结果:经治疗后,治疗组HAMD-17评分、UPDRS-Ⅲ评分和PDQ-39评分均明显下降,差异具有统计学意义(P<0.05),PDSS评分较前升高,差异具有统计学意义(P<0.05),且治疗前后评分差值的相关性分析示HAMD-17差值与UPDRS-Ⅲ、PDQ-39差值呈现正相关,与PDSS差值呈现负相关(UPDRS-Ⅲ:r=0.54;PDQ-39:r=0.53;PDSS:r=-0.50)。研究过程中未见严重不良事件。结论:靳三针调神针法对轻中度PDD患者有较好的临床疗效及安全性,且PDD患者抑郁状况改善与运动情况、生活质量及睡眠情况改善具有相关性。

Objective:To observe the clinical efficacy and safety of JIN's three-needle regulating Shen acupuncture in treatment of mild-to-moderate Parkinson's disease depression(PDD).Methods:72 patients who met the inclusion criteria were divided into the control group and the treatment group,with 36 cases in each group.The control group was given basic treatment;on which basis,the treatment group was treated with JIN's three-needle regulating Shen acupuncture.The scores of Hamilton Depression Scale-17 items(HAMD-17),Unified Parkinson's Disease Rating Scale-PartⅢ(UPDRS-Ⅲ),39-item Parkinson's Disease Quality of Life Questionnaire(PDQ-39)and Parkinson's Disease Sleepiness Scale(PDSS)were compared between before and after the treatment in the two groups;PDQ-39 scores on the 30th day of the post-treatment and adverse events were observed in the two groups as well.Results:The scores of HAMD-17,UPDRS-Ⅲand PDQ-39 were decreased significantly(P<0.05),and PDSS score was increased after the treatment compared with those before the treatment in the treatment group(P<0.05).In terms of the correlation analysis,the pre-treatment and post-treatment differences of HAMD-17 scores showed a positive correlation with the pre-treatment and post-treatment scores differences of UPDRS-Ⅲand PDQ-39,and a negative correlation with the score difference of PDSS(UPDRS-Ⅲ:r=0.54;PDQ-39:r=0.53;PDSS:r=-0.50).During the treatment period,there were no serious adverse reactions occurring in the two groups.Conclusion:JIN's three-needle regulating Shen acupuncture has good efficacy and safety in treatment of mild-to-moderate PDD,and the improvement of depression is correlated with the improvement of movement,quality of life and quality of sleep.