督脉灸联合温肾健脾解郁方对慢性疲劳综合征患者疲劳状态和氧化应激、免疫功能的影响

Effects of Du Meridian Moxibustion Combined with Wenshen Jianpi Jieyu Formula on Fatigue State,Oxidative Stress and Immune Function in Patients with Chronic Fatigue Syndrome

目的:探讨督脉灸联合温肾健脾解郁方治疗对慢性疲劳综合征(CFS)患者疲劳状态和氧化应激、免疫功能的影响。方法:CFS患者100例随机分为对照组与试验组,每组50例。对照组予以常规西医治疗,试验组于对照组治疗基础上予以督脉灸联合温肾健脾解郁方治疗,两组均治疗8周。分别于治疗前后,对患者进行疲劳量表(FS-14)、气虚证候积分、抑郁自评量表(SDS)、匹兹堡睡眠质量指数(PSQI)和健康调查简表(SF-36)的评定,并检测患者血清氧化应激指标[超氧化物歧化酶(SOD)、过氧化脂质(LPO)]和CD4^(+)、CD8^(+)水平。结果:对照组有效率74.00%(31/50),试验组总有效率94.00%(47/50),差异具有统计学意义(P<0.05)。治疗后,试验组FS-14症状评分和气虚证候积分与对照组比较显著下降,差异具有统计学意义(P<0.05),且试验组SDS评分、PSQI评分低于对照组,差异具有统计学意义(P<0.05),SF-36评分高于对照组,差异具有统计学意义(P<0.05)。治疗后,相比对照组,试验组有着较高的SOD水平和较低的LPO水平,差异具有统计学意义(P<0.05)。治疗后,试验组相比对照组有着较高的CD4^(+)水平和CD4^(+)/CD8^(+)比值,差异具有统计学意义(P<0.05)。结论:督脉灸联合温肾健脾解郁方治疗CFS患者可提高治疗效果,改善患者疲劳等临床症状,其机制可能与调节氧化应激和免疫功能有关。

Objective:To investigate the effects of Du meridian moxibustion combined with Wenshen Jianpi Jieyu Formula on fatigue state,oxidative stress and immune function in patients with chronic fatigue syndrome(CFS).Methods:100 patients with CFS were randomly divided into the control group and the study group,with 50 cases in each group.The control group was treated with conventional Western medication;on which basis,the study group was also treated with Du meridian moxibustion combined with Wenshen Jianpi Jieyu Formula.Both groups were treated for 8 weeks.The scores of fatigue scale(FS-14),Qi deficiency syndrome,self-rating depression scale(SDS),Pittsburgh sleep quality index(PSQI),health survey summary(SF-36)were evaluated,the serum levels of oxidative stress indexes,including superoxide dismutase(SOD)and lipid peroxide(LPO),as well as the serum levels of CD4^(+)and CD8^(+)were detected before and after the treatment in the two groups.Results:The total effective rate of the study group 94.00%(47/50),which was significantly higher than 74.00%(37/50)in the control group(P<0.05).After the treatment,the scores of FS-14 and Qi deficiency syndrome were significantly decreased in the study group compared with those in the control group(P<0.05).The scores of SDS and PSQI were lower in the study group than those in the control group(P<0.05),whereas the score of SF-36 was higher in the study group than that in the control group(P<0.05).The level of SOD was higher and the level of LPO was lower in the study group than those in the control group(P<0.05).The levels of CD4^(+)and CD4^(+)/CD8^(+)were higher in the study group than those in the control group(P<0.05).Conclusion:Du meridian moxibustion combined with Wenshen Jianpi Jieyu Formula can improve therapeutic effect and clinical symptoms in treatment of CFS.The mechanism may be related to the regulation of oxidative stress and immune function.