胃内微生态与胃癌:关系、机制与临床价值

Gastric microbiome and gastric cancer:Relationship,mechanism,and clinical significance

胃内菌群与胃癌(gastric cancer,GC)的关系是近年来的研究热点之一.研究发现胃内菌群通过多种途径参与GC发生,且在肿瘤发展过程中出现特征性改变.幽门螺杆菌被认为是Ⅰ类致癌原,在GC发展中发挥重要作用.近年来,越来越多研究发现非幽门螺杆菌同样参与GC发展.本文通过检索知网、PubMed、Web of Science,围绕胃内微生态与GC的相互关系、作用机制及临床价值展开综述,以期为GC的临床诊疗提供新思路.

The relationship between gastric microbiome and gastric cancer has been one of the research focuses in recent years.Many studies have found that gastric microbiome is involved in the occurrence of tumor through several ways,and appears to have characteristic changes in the development of gastric cancer.Helicobacter pylori(H.pylori)is considered a class I carcinogen,which plays an important role in the development of gastric cancer.More studies have recently discovered that bacteria other than H.pylori are also responsible for the growth of gastric cancer.In this review,by searching CNKI,PubMed,and Web of Science,we provide an overview on the connection,mechanism,and clinical significance between gastric microbiome and gastric cancer,with an aim to offer fresh perspectives on the diagnosis and treatment of gastric cancer.