个体化治疗对有上消化道症状Hp胃炎患者的临床疗效

Clinical efficacy of individualized therapy for paients with upper gastrointestinal symptoms of Hp gastritis

目的 探讨个体化治疗对有上消化道症状的Hp胃炎患者的临床疗效,为临床诊治提供参考。方法 选取2021年1月至2021年12在济宁医学院附属医院消化内科门诊治疗的有上消化道症状的238例Hp胃炎患者,随机分为对照组(117例)和观察组(121例),对照组直接抗Hp治疗,观察组在抗Hp治疗前针对上消化道症状首先进行个体化对症治疗,后给予抗Hp治疗。停药后一月比较两组临床疗效和Hp根除率。结果 观察组除嗳气外其余上消化道相关症状好转率明显高于对照组(P<0.05);观察组Hp根除率(96.7%)明显高于对照组(89.5%)(χ^(2)=4.741,P<0.05)。结论 对于有上消化道症状的Hp胃炎患者,抗Hp治疗前首先给予个体化治疗可以提高上消化道症状疗效及提高Hp根除率。

Objective To explore the clinical effect of individual therapy on Hp gastritis patients with upper gastrointestinal symptoms,and to provide reference for clinical diagnosis and treatment.Methods A total of 238 Hp gastritis patients with upper digestive tract symptoms treated in the outpatient department of gastroenterology,Affiliated Hospital of Jining Medical College from January 2021 to December 2021 were selected and randomly divided into control group(117 cases) and experimental group(121 cases).The control group received direct anti-HP treatment.In the experimental group,the upper gastrointestinal symptoms were first treated with individualized symptomatic treatment before anti-HP treatment,and then anti-HP treatment was given.The clinical efficacy and Hp eradication rate of the two groups were compared one month after withdrawal.Results The improvement rate of upper digestive tract related symptoms in the experimental group except belching was significantly higher than that in the control group(P<0.05).The eradication rate of Hp in the experimental group(96.7%) was significantly higher than that in the control group(89.5%)(χ^(2)=4.741,P<0.05).Conclusion For Hp gastritis patients with upper digestive tract symptoms,individual treatment before anti-HP treatment can improve the efficacy of upper digestive tract symptoms and improve the eradication rate of Hp.