MCP-1在2型糖尿病中的作用

Advances in the study of the role of MCP-1 in type 2 diabetes mellitus

2型糖尿病(T2DM)是一种常见的内分泌慢性代谢性疾病,其发病率逐年升高,呈现年轻化的趋势,且长期慢性高血糖易引起多种并发症,影响人类的生活质量,已成为严重危害人类生命健康的疾病,但对于其发病机制目前尚不明确。单核细胞趋化蛋白-1(monocytechemotactic protein 1,MCP-1)作为CC趋化因子家族中的一员,参与多种自身免疫性疾病的发生发展。目前已有的研究结果显示,MCP-1与T2DM并发症中的大血管、微血管病变及神经病变相关联,可能参与其发病机制。本文就MCP-1在T2DM及其并发症中的研究进展作一论述。

Type 2 diabetes mellitus(T2DM) is a common endocrine chronic metabolic disease,the incidence of which is increasing year by year,presenting a trend of rejuvenation,and long-term chronic hyperglycemia is prone to cause a variety of complications,which affects the quality of life of the patients,and it has become a disease that seriously jeopardizes the life and health of human beings,but the pathogenesis of the disease is still not clear.As a member of the CC chemokine family,monocyte chemotactic protein 1(MCP-1) is involved in the development of a variety of autoimmune diseases,and the results of current studies have shown that MCP-1 is associated with macrovascular and microvascular lesions and neurological complications of T2DM,and may be involved in its pathogenesis.In this article,we discuss the research progress of MCP-1 in type 2 diabetes mellitus and its complications.