透明细胞肾细胞癌组织中PBRM1和BAP1表达缺失对患者预后的影响

Effect of loss of PBRM1 and BAP1 expression in clear cell RCC tissues on patient outcome

目的:检测透明细胞肾细胞癌(clear cell renal carcinomas,cc-RCC)组织中PBRM1和BAP1的表达情况,探讨两者临床病理特征及对肾癌患者预后的影响。方法:采用免疫组化Elivision检测60例cc-RCC组织和16例正常肾组织中PBRM1和BAP1的表达。结果:60例cc-RCC组织中PBRM1和BAP1的高表达阳性率分别为46.7%和35%,对照组16例正常肾组织中PBRM1和BAP1均强阳性表达。PBRM1和BAP1表达缺失与cc-RCC高核级、肿瘤晚期及肿瘤组织坏死密切相关(P<0.05)。PBRM1表达缺失患者的PFS(P=0.002)和OS(P=0.036)低于PBRM1高表达患者。结论:PBRM1在cc-RCC缺失表达可能促使肿瘤侵袭与转移,是预后不良的标志。

Objective:To detect the expressions of PBRM1 and BAP1,evaluate the prognostic impact of immunohistochemical expression of BAP1 and PBRM1 in patients with clear cell renal carcinomas(cc-RCC).Methods:Immunohistochemistry was used to detect the expressions of PBRM1 and BAP1 in cc-RCC tissues of 60 patients and 16 normal renal samples.Results:The positive-expression rates of PBRM1 and BAP1 in the cc-RCC were 46.7%and 35%respectively,were strongly positive-expression in control group.Loss-expression of PBRM1 and BAP1 in the cc-RCC tissues were significantly correlated with the high nuclear grade,advanced tumor and tumor necrosis(P<0.05).Loss-expression of PBRM1 had inferior PFS(P=0.002)and OS(P=0.036)compared with that positive-expression in cc-RCC patients.Conclusion:Loss-expression of PBRM1 may promote tumor invasion and metastasis,is a sign of poor prognosis in cc-RCC patients.