龙胆泻肝汤联合手术治疗原发性青光眼疗效及对血清氧化应激指标的影响

Effect of Longdan Xiegan Decoction(龙胆泻肝汤)Combined with Surgery in Treatment of Patients with Primary Glaucoma and Its Influence for Serum Oxidative Stress Indexes

目的 探讨龙胆泻肝汤联合手术治疗原发性青光眼的疗效及对血清氧化应激指标的影响。方法 将医院于2019年1月—2022年10月收治的66例原发性青光眼患者依据随机的原则分为两组。对照组33例进行常规复合式小梁切除术治疗,观察组33例在对照组基础上加用龙胆泻肝汤。然后将两组中不同分类患者的总有效率、治疗前后的眼压、前房深度、房水流畅系数及血清氧化应激指标进行比较。结果 观察组治疗后不同分类的总有效率均高于对照组,治疗后不同时间的眼压、前房深度、房水流畅系数及血清氧化应激指标均明显优于治疗前和对照组同时间的检测结果,均P<0.05,均差异有统计学意义。结论 龙胆泻肝汤联合手术治疗原发性青光眼患者中的疗效较好,且对血清氧化应激指标的影响也更为明显。

Objective To study the effect of Longdan Xiegan Decoction(龙胆泻肝汤)combined with surgery in the treatment of patients with primary glaucoma and its influence for the serum oxidative stress indexes.Methods Sixty-six patients with pri-mary glaucoma in the hospital from January 2019 to October 2022 were divided into two groups according to random principle.The control group(33 cases)were treated with conventional compound trabeculectomy and the observation group(33 cases)were treated with Longdan Xiegan Detection on the treatment of control group.Then the total effective rates of different types,intraocu-lar pressure,anterior chamber depth,coefficient of outflow facility and serum oxidative stress indexes before and after the treat-ment in two groups were compared.Results The total effective rates of different types of glaucoma in the observation group were higher than those of the control group and intraocular pressure,anterior chamber depth,coefficient of outflow facility and serum oxidative stress indexes of the observation group after the treatment were all obviously better than those before treatment and those of control group at the same time and there were all significant differences(all P<0.05).Conclusion The effect of Longdan Xie-gan Decoction combined with surgery in the treatment of patients with primary glaucoma and its influence for the serum oxidative stress indexes are better,and its influence for the serum oxidative stress indexes is also more obvious.